Scleroderma, Systemic Clinical Trial
Official title:
Comparative Study Between Systemic Sclerosis and Other Rheumatic Diseases for Health-related Quality of Life in Korean Patients
To compare the health related quality of life of patients with systemic sclerosis with other rheumatic diseases, such as rheumatoid arthritis, systemic lupus erythematosus and Sjogren's syndrome.
Systemic sclerosis (SSc) is a connective tissue disease characterized by vasculopathy,
fibrosis, and autoimmunity. The prognosis of the disease depends on the nature and severity
of organ involvement. Patients with SSc suffer from digital ulceration, arthritis,
progressive skin tightening, and joint contractures that cause pain and limitation of limb
function. The cardiopulmonary system may also be severly affected by SSc in the form of
interstitial lung disease and pulmonary arterial hypertension, which leads to reduction in
exercise capacity and symptomatic dyspnea. Gastrointestinal involvement by SSc may cause
malnutrition, and SSc renal crises may result in renal failure. In addition, cosmetic
disfigurement resulting from facial and limb skin involvement may lead to social isolation,
mood problems, and significant work disability.
It has been reported that health related quality of life (HRQoL) is significantly impared in
SSc patients compared to the general population. Moreover, the degree of impairment in SSc
patients was comparable to those who suffered from other chronic illnesses such as heart and
lung disease, hypertension, diabetes mellitus, and depression. However, there were no studies
yet comparing the HRQoL of SSc patients with other rheumatic diseases, such as rheumatoid
arthritis (RA) and systemic lupus erythematosus (SLE). Especially, information regarding the
impact of SSc on functioning and HRQoL in Korean patients is lacking.
Therefore, the investigators plan to compare the functioning and HRQoL of patients with SSc
with other rheumatic diseases, such as RA, SLE, and Sjogrens's syndrome, and healthy
controls. A validated Korean version of the Medical Outcomes Study Short Form 36 (SF36)
questionnaire and the EuroQol five dimensions questionnaire (EQ-5D) will be used in this
study.
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