Sciatica Clinical Trial
Official title:
A Multicenter, Randomized, Double-Blinded, Placebo-Controlled Study Using a Bayesian Adaptive Design to Assess the Efficacy, Safety, Tolerability, and Serum Exposure of Multiple Doses of BG00010 (Neublastin) in Subjects With Painful Lumbar Radiculopathy
The primary objective of the study is to assess the efficacy of Intravenous (IV) BG00010
(Neublastin) in improving pain in painful lumbar radiculopathy participants when
administered 3 times per week for 1 week.
The secondary objectives of this study in this study population are as follows: To explore
the duration of the effect of BG00010 in improving pain; To explore the dose response curve
on pain reduction; To assess the safety and tolerability of BG00010; To assess the serum
exposure to BG00010.
During the study, frequent assessment of allocation probability will be conducted to guide subsequent randomization of participants into dose groups. ;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02384928 -
Effects of Shinbaro Pharmacopuncture in Sciatic Pain Patients With Lumbar Disc Herniation
|
N/A | |
| Completed |
NCT05626140 -
COMPARISON OF EFFICACY OF DIFFERENT DRUG COMBINATIONS IN ACUTE SCIATICA
|
Phase 3 | |
| Withdrawn |
NCT02313350 -
Intradiscal Discogel® in Resistant Sciatica
|
N/A | |
| Unknown status |
NCT02512081 -
"The Lived Experience of Investigations for Sciatica"
|
N/A | |
| Recruiting |
NCT06179901 -
The Effect of Early MSAT Treatment on Sciatica Caused by Traffic Accidents
|
N/A | |
| Terminated |
NCT02951377 -
Mechanical Diagnosis and Treatment and/or Steroid Injections for Lumbar Radiculopathy
|
Phase 1 | |
| Completed |
NCT03347929 -
NSAIDs in Sciatica NSAIDS IN SCIATICA
|
Phase 4 | |
| Completed |
NCT04145310 -
BOL-DP-o-04 in Patients With Low Back Pain and Sciatica
|
Phase 1/Phase 2 | |
| Enrolling by invitation |
NCT04660656 -
Predictive Value of the Five-repetition Sit-to-stand Test After Lumbar Spine surgerySTS-3 Study.
|
||
| Completed |
NCT02644421 -
Clinical Trial to Evaluate the Safety and Analgesic Efficacy of VVZ-149 in Lumbar Radiculopathy (Sciatica)
|
Phase 1 | |
| Completed |
NCT00991172 -
A Study to Evaluate the Safety and Efficacy of Subcutaneously Administered REGN475(SAR164877) in Patients With Sciatic Pain
|
Phase 2 | |
| Completed |
NCT00668434 -
Effectiveness of Oral Prednisone in Improving Physical Functioning and Decreasing Pain in People With Sciatica
|
Phase 2 | |
| Completed |
NCT00749996 -
Herniectomy Versus Herniectomy With a Spinal Stabilization System for the Treatment of Complex Disc Disease
|
Phase 4 | |
| Completed |
NCT00246948 -
The Efficacy of Active Conservative Treatment for Patients With Severe Sciatica. A Randomized Clinical Controlled Trial
|
N/A | |
| Completed |
NCT04155450 -
Effects of Extension Biased External Limb Loading in Addition to McKenzie Extension Protocol in Lumbar Derangement Syndrome
|
N/A | |
| Completed |
NCT02284542 -
NAPS: Non-awake Versus Awake Placement of Spinal Cord Stimulators
|
||
| Recruiting |
NCT02770963 -
Efficacy of Acupuncture for Discogenic Sciatica
|
N/A | |
| Completed |
NCT00364572 -
Efficacy of Epidural Etanercept in the Treatment of Sciatica
|
Phase 1/Phase 2 | |
| Completed |
NCT00470509 -
Adalimumab in Severe and Acute Sciatica
|
Phase 2 | |
| Active, not recruiting |
NCT03887962 -
Virtual Environment Rehabilitation for Patients With Motor Neglect Trial
|
N/A |