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Clinical Trial Summary

The primary objective of this study is to assess the effects of 'Seroquel-XR' on the verbal learning ability in people with at-risk mental state (ARMS) over a 12 week period. The verbal learning ability will be indexed by delayed free recall score of CVLT(California Verbal learning Test), a standard neuropsychological verbal memory tests.

The secondary objective is to assess the effects of 'Seroquel-XR' on other cognitive function and psychiatric symptoms including psychotic, anhedonic symptoms, and impulsivity. The cognitive function abilities will be measured by standard neuropsychological tests as follows;

- Working memory: verbal & spatial 2-back test

- Attention: Digit Span, 3-7 CPT(Continuous Performance Test)

- Executive function: WCST (Wisconsin Card Sorting Test)

- Visuo-spatial ability: Rey Complex Figure Task copy

- Visuomotor speed and planning: Trail making test A & B

- Verbal fluency: Controlled Oral Word Association Test(COWAT) The scales of psychiatric symptoms which will be used are as follows;

- Psychotic symptoms: Scales of Prodromal scales (SOPS), Positive and negative syndrome scale (PANSS)

- Anhedonia: Social Anhedonia Scale (SAS), Physical Anhedonia Scale (PAS)

- Social cognition: Ambiguous Intention Hostility Questionnaire (AIHQ)

- Impulsivity: Barrett Impulsivity Scale (BIS)


Clinical Trial Description

n/a


Study Design

Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment


Related Conditions & MeSH terms


NCT number NCT01250847
Study type Interventional
Source Severance Hospital
Contact Suk Kyoon An, MD, Ph D.
Phone +82 17 349 8275
Email ansk@yuhs.ac
Status Recruiting
Phase Phase 4
Start date November 2010
Completion date October 2012

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