Schizophrenia and Related Disorders Clinical Trial
Official title:
Repetitive Transcranial Magnetic Stimulation (rTMS) to Improve Gesture Control in Schizophrenia: A Randomised, Placebo-controlled, Double-blind Crossover Trial
The majority of schizophrenia patients is impaired in hand gesture performance, which contributes to poor functional outcome and poor communication skills. The left inferior frontal gyrus (IFG) and the left inferior parietal lobe (IPL) are key nodes of the gesture network, which is less active in patients with schizophrenia. Here, the investigators test single sessions of rTMS/TBS known to either enhance or inhibit local brain activity for app. 1 hour. The investigators aim to determine, which protocol may improve gesture performance in patients and healthy controls. This is a randomized, double-blind, cross-over, placebo-controlled single-center trial in 20 patients with schizophrenia spectrum disorders and 20 healthy controls. Gesture performance will be tested immediately after each TMS session, which are separated by 48 hours. Results of this study will inform larger interventional trials comparing 2 TMS protocols with repeated administration.
Schizophrenia is associated with poor social functioning, which is perturbed by deficits in social interaction including nonverbal communication. The use of hand gestures is critical for nonverbal communication, but the majority of schizophrenia patients has severe gesture impairments. Today no intervention may ameliorate gesture impairments. Patients with gesture impairments have altered structure and function of the gesture network, particularly the left inferior frontal gyrus (IFG) and also the left inferior parietal lobe (IPL). Noninvasive brain stimulation techniques may alter local brain function. Repetitive transcranial magnetic stimulation (rTMS) and particularly theta burst stimulation (TBS) for a few mins is a very safe method to alter brain states locally for approximately 1 hour. Indeed, facilitatory stimulation of the left frontal cortex by transcranial direct current stimulation (tDCS) demonstrated improved gesture perception and interpretation in healthy subjects. In addition, inhibitory stimulation with continuous theta burst stimulation (cTBS) over left IFG may perturb gesture performance in healthy subjects. Thus, the investigators hypothesize that local changes of brain activity within the gesture network would change gesture performance. Particularly, facilitatory intermittent theta burst stimulation (iTBS) of the left IFG would improve gesture performance. The investigators will test single sessions of rTMS in healthy subjects and schizophrenia patients. If one of the protocols proves to have superior effects, this result will help to plan interventional trials targeting social interaction deficits in schizophrenia. The aim of the study is to determine the effect of one session of iTBS over the left IFG on gesture performance compared to cTBS over the right IPL (active comparator) and one placebo rTMS sessions. This is a randomized, double-blind, cross-over, placebo-controlled single-center trial in 20 patients with schizophrenia spectrum disorders and 20 healthy controls. After baseline assessment of gesture performance, participants will receive one rTMS protocol at each time point, immediately followed by assessments of gesture performance and dexterity. rTMS sessions will be separated by 48 hours. Gesture performance will be measured with video recorded Test of Upper Limb Apraxia, which is rated blindly according to a manual. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT05083377 -
Clozapine Use Pattern in the Province of Seville
|
||
Recruiting |
NCT06313918 -
Exercise Therapy in Mental Disorders-study
|
N/A | |
Recruiting |
NCT06134661 -
Accelerated rTMS for Psychomotor Slowing
|
N/A | |
Completed |
NCT01433094 -
Study on Psychoeducation Enhancing Results of Adherence in Schizophrenia
|
N/A | |
Terminated |
NCT05526833 -
An Extension Protocol for Patients Who Previously Completed the TMS Pilot Study
|
N/A | |
Recruiting |
NCT05982158 -
Avatar-mediated Therapy Versus Cognitive Behavioural Therapy for Persisting Experiences of Hearing Voices
|
N/A | |
Active, not recruiting |
NCT06175559 -
Embedded Narrative in Interactive Game Design for Improving Medication Adherence of Schizophrenia
|
N/A | |
Active, not recruiting |
NCT05673941 -
"InMotion" - Physical Training With Creative Movement as an Intervention for Adults With Schizophrenia
|
N/A | |
Recruiting |
NCT02916810 -
TMS for Symptom Reduction in Schizophrenia
|
N/A | |
Recruiting |
NCT03525054 -
Semantic and Syntactic Computerized Analysis of Free Speech
|
||
Recruiting |
NCT05389345 -
tDCS and Executive Function Training for Schizophrenia
|
N/A | |
Completed |
NCT05601050 -
Linguistic Predictors of Outcomes in Psychosis
|
||
Not yet recruiting |
NCT05603104 -
Intensified Pharmacological Treatment for Schizophrenia, Major Depressive Disorder and Bipolar Depression After a First-time Treatment Failure
|
Phase 3 | |
Not yet recruiting |
NCT05958875 -
The Effect of a Six Week Intensified Pharmacological Treatment for Schizophrenia Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment.
|
Phase 4 | |
Completed |
NCT03075202 -
Role of an E-cigarette on Smoking Displacement in Smokers With Schizophrenia
|
||
Completed |
NCT03921450 -
Overcoming Psychomotor Slowing in Psychosis (OCoPS-P)
|
N/A | |
Completed |
NCT06231407 -
Increasing Medication Check Participation Through Applying CT-r
|
N/A | |
Recruiting |
NCT04478838 -
"Extended" (Alternate Day) Antipsychotic Dosing
|
Phase 4 | |
Active, not recruiting |
NCT04366401 -
Efficacy of Prebiotic and Probiotic Dietary Modulation in Schizophrenic Disorders
|
N/A | |
Completed |
NCT04612777 -
A Trial of "Opening Doors to Recovery" for Persons With Serious Mental Illnesses
|
N/A |