SARS-CoV Infection Clinical Trial
Official title:
Is Remdesivir a Possible Therapeutic Option for SARS-CoV-2 : An Interventional Study
Remdesivir is a monophosphoramidate prodrug of an adenosine analogue and it has a
broad-spectrum antiviral activity against paramyxoviruses, falviviruses and coronaviruses. It
showed in vitro activity on human airway epithelial cells against SARS-CoV-2. It is an
investigational drug and granted an Emergency Use Authorization by Food and Drug
Administration FDA, so it is under clinical trial.
The potent mechanism of action of this drug is still unclear but it effects through several
processes. It can interfere with nsp12 polymerase even when exoribonuclease proofreading is
intact. It can also produce nucleoside triphosphate NTP that acts pharmacologically active
alternate substrate of RNA-chain terminator, as a result NTP can constrain active
triphosphates into viral RNA of coronaviruses. There is evidence of high genetic barrier to
develop resistance against Remdesivir in coronavirus as a result of which is maintains its
effectiveness in antiviral therapies against these viruses. Effectiveness of Remdesivir has
been reported against different groups of coronaviruses including Alphacoronavirus NL63 and
several SARS/MERS-CoV coronaviruses.
This is interventional single-center study, that will be done at Lahore General Hospital in
which 95 beds are allocated for COVID-19 patients including ICUs and HDUs. Ethical approval
will be obtained from research ethical committee of Lahore General hospital, Lahore. Informed
consent will be obtained from all patients who will agree to publish their data in this
research. Patient's privacy protection will be obeyed with the Helsinki Declaration.
The aim of this study is to evaluate clinical effectiveness of this investigational drug,
started a clinical trial of this drug on laboratory-confirmed COVID-19 patients at a tertiary
care hospital of Lahore, Pakistan.
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