Maximizing the Dietary Pattern of Older Adults: the Effects of Protein Intake on Protein Kinetics

Sarcopenia Clinical Trial

Official title:

Maximizing the Dietary Pattern of Older Adults: the Effects of Protein Intake on Protein Kinetics

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04830514
• Other study ID #: 262424
• Status: Completed
• Phase: N/A
• Start date: May 27, 2021
• Est. completion date: March 15, 2022

Study information

• Verified date: October 2022
• Source: University of Arkansas
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

A randomized study to demonstrate how animal-based protein-rich food sources can be used by older adults to increase protein intake within pre-existing dietary patterns.

Description:

Current dietary patterns of older Americans will be augmented by readily available quality protein sources. Investigators will observe the effects of recommended and common protein intakes on the maintenance of whole-body protein balance and potential for muscle protein anabolism.

3 groups of 10 older subjects will be studied during daily protein intakes. Study duration per subject will be about 2 weeks.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 44
• Est. completion date: March 15, 2022
• Est. primary completion date: March 15, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 50 Years to 70 Years

Eligibility

Inclusion Criteria:

• BMI = 35 kg/m2

• Capable of providing informed consent

• COVID-19 negative and/or asymptomatic

Exclusion Criteria:

• Subject who does not/will not eat animal protein sources.

• Body mass index > 35.

• History of chemotherapy or radiation therapy for cancer in the 6 months prior to enrollment.

• Use of insulin to control blood sugar level.

• Currently receiving androgen (e.g., testosterone) or anabolic (e.g., GH, IGF-I) therapy.

• Currently using prescription blood thinning medications.

• Unable or unwilling to suspend aspirin use for 7 days prior to Visit 3.

• Unwilling to avoid using protein or amino-acid supplements during participation.

Related Conditions & MeSH terms

• Sarcopenia

Intervention

Other:
• Recommended Dietary Allowance of Protein
0.8 g/kg/day protein intake
• Habitual protein intake
1.0 g/kg/day protein intake
• Optimal Protein Intake
1.5 g/kg/day protein intake

Locations

Country	Name	City	State
United States	University of Arkansas for Medical Sciences	Little Rock	Arkansas

Sponsors (1)

Lead Sponsor	Collaborator
University of Arkansas

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Whole Body Protein Turnover	Isotope Tracer	24 hour