ROS1-fusion Positive Tumor Clinical Trial
Official title:
ALCMI-006: A Prospective Biospecimen Collection Study From Patients With ROS1-Fusion Positive Tumors
Patient Derived Xenografts (PDXs) are models to study tumor growth, response to anti-cancer therapies, and resistance to anti-cancer therapies. The purpose of this study is to develop up to 24 PDX models for ROS1-fusion driven cancers to be used for research purposes only. That is, these patient derived PDX models will have no immediate benefit to the patient from whom the tumor specimen was obtained. Rather, these PDX models will be used to inform the study of ROS1-fusion driven cancers at large.
ROS1-fusions occur in several cancer types such as non-small cell lung cancer, gastric
cancer, ovarian cancer, glioblastoma, cholangiocarcinoma and melanoma. In each of these
cancers, ROS1-fusions account for a small sliver of the pie, accounting for 1-2% of all
diagnoses, forming a relatively rare molecular subset of cancer. The Addario Lung Cancer
Medical Institute (ALCMI) would like to focus on this under-studied rare molecular subset of
cancer to understand how cancer begins and spreads in these tumors, how these tumors respond
to treatment and what happens when tumors stop responding to treatment. Therefore, in
collaboration with cancer patients whose tumors have ROS1-fusions (known as the "ROS1ders"),
we are studying ROS1-fusions across all cancer types.
Patient Derived Xenografts (PDXs) are models to study cancer. These models are developed by
injecting a fresh piece of tumor specimen from a patient into a special type of mouse, which
then acts as 'host' to allow the tumor to grow. Peer-reviewed and published experimental
studies have shown that PDX models can maintain features similar to the original tumor from
the patient. PDX models can be used to study tumor growth, response to anti-cancer therapies,
and resistance to anti-cancer therapies.
The purpose of this study is to develop up to 24 PDX models for ROS1-fusion driven cancers to
be used for research purposes only. That is, these patient derived PDX models will have no
immediate benefit to the patient from whom the tumor specimen was obtained. Rather, these PDX
models will be used to inform the study of ROS1-fusion driven cancers at large.
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