RheumatoId Arthritis Clinical Trial
Official title:
Transplantation of Autologous Purified Bone Marrow Derived Specific Populations of Stem Cells and Mesenchymal Stem Cells in Patients With Rheumatoid Arthritis
Verified date | March 2020 |
Source | Stem Cells Arabia |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Rheumatoid arthritis is a chronic systemic disease, which is characterized by chronic inflammation in the synovial tissue. Rheumatoid arthritis ultimately results in the destruction of cartilage, bone and ligaments and joint deformity. The underlying hypothesis is that autologous bone marrow-derived mesenchymal and specific populations of stem cells has anti-inflammatory and regenerative effects and thus potentially alleviates the progression of rheumatoid arthritis. The study is to explore the safety and efficacy of BM-SC transplantation in treatment of rheumatoid arthritis.
Status | Active, not recruiting |
Enrollment | 100 |
Est. completion date | February 2022 |
Est. primary completion date | December 2021 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 17 Years to 75 Years |
Eligibility |
Inclusion Criteria: - 17-75 years old - The presence of osteoarthritis based on MRI and American Rheumatism Association criteria since 6 months before treatment. Exclusion Criteria: - Subjects with addition major health condition/disease diagnoses - Subjects that are pregnant or breastfeeding |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Stem Cells Arabia |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Evaluation of Pain Reduction measured by VAS scaling | measured by VAS scaling | 1 month | |
Secondary | Evaluation of the Physical Activity measure by WOMAC scoring | 1 month | ||
Secondary | Evaluation the resurfacing of articular cartilage by MRI | 6 months |
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