Rheumatoid Arthritis Clinical Trial
Official title:
Improving Influenza Immunization Responses in Rheumatoid Arthritis: A Strategy To Enhance Protection Against A Preventable Cause Of Death In An At Risk Population?
Influenza, a vaccine-preventable respiratory disease, is ranked 8th among the causes of death
in the Canadian population. Among rheumatoid arthritis (RA) patients, the incidence of both
seasonal influenza and serious influenza-related illness (IRI) are increased. Despite being a
high priority group targeted for vaccination, the diagnosis of RA and other patient-specific
factors (i.e. older age, treatment, current smoking) are linked to impaired vaccination
responses.
Thus the burden of influenza among people with RA is disproportionally high, and
interventions to improve responses to influenza vaccination are urgently needed. Strategies
to optimize protection in another vulnerable group, the elderly, include the use of
quadrivalent vaccines, higher antigen doses, and adjuvants. A high-dose, trivalent,
inactivated influenza vaccine (HD-TIV) has recently been shown to have a similar safety
profile to standard dose vaccine (SD-TIV) with improved immunogenicity and protection in
adults ≥65 years of age. Whether or not analogous strategies to improve responses to
influenza vaccine will enhance protection in people with RA is unknown. The investigators
hypothesize that the use of the HD-influenza vaccine will improve vaccine-induced protection
(i.e. seroconversion and seroprotection) in people with RA compared to SD-influenza vaccine.
The investigators propose to conduct a stratified, randomized, modified double blind,
active-controlled trial to assess immune responses to two commercial influenza vaccines
containing different antigen doses in individuals with RA.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04226131 -
MusculRA: The Effects of Rheumatoid Arthritis on Skeletal Muscle Biomechanics
|
N/A | |
| Completed |
NCT04171414 -
A Study to Evaluate Usability of Subcutaneous Auto-injector of CT-P17 in Patients With Active Rheumatoid Arthritis
|
Phase 3 | |
| Completed |
NCT02833350 -
Safety and Efficacy Study of GDC-0853 Compared With Placebo and Adalimumab in Participants With Rheumatoid Arthritis (RA)
|
Phase 2 | |
| Completed |
NCT04255134 -
Biologics for Rheumatoid Arthritis Pain (BIORA-PAIN)
|
Phase 4 | |
| Recruiting |
NCT05615246 -
Exactech Humeral Reconstruction Prosthesis of Shoulder Arthroplasty PMCF (HRP)
|
||
| Completed |
NCT03248518 -
Lessening the Impact of Fatigue in Inflammatory Rheumatic Diseases
|
N/A | |
| Completed |
NCT03514355 -
MBSR in Rheumatoid Arthritis Patients With Controlled Disease But Persistent Depressive Symptoms
|
N/A | |
| Recruiting |
NCT06005220 -
SBD121, a Synbiotic Medical Food for RA Management
|
N/A | |
| Recruiting |
NCT05451615 -
Efficacy and Safety of Abatacept Combined With JAK Inhibitor for Refractory Rheumatoid Arthritis
|
Phase 3 | |
| Completed |
NCT05054920 -
Eccentric Versus Concentric Exercises for Rotator Cuff Tendinopathy in Patients With Rheumatoid Arthritis
|
N/A | |
| Completed |
NCT02037737 -
Impact and Use of Abatacept IV for Rheumatoid Arthritis in Real Life Setting
|
N/A | |
| Recruiting |
NCT04079374 -
Comparative Efficacy, Safety and Immunogenicity Study of Etanercept and Enbrel
|
Phase 3 | |
| Completed |
NCT02504268 -
Effects of Abatacept in Patients With Early Rheumatoid Arthritis
|
Phase 3 | |
| Recruiting |
NCT05496855 -
Remote Care in People With Rheumatoid Arthritis
|
N/A | |
| Completed |
NCT05051943 -
A Study of the Real-world Use of an Adalimumab Biosimilar and Evaluation of Nutritional Status on the Therapeutic Response
|
||
| Recruiting |
NCT06103773 -
A Study of Single and Multiple Oral Doses of TollB-001
|
Phase 1 | |
| Recruiting |
NCT06031415 -
Study of GS-0272 in Participants With Rheumatoid Arthritis
|
Phase 1 | |
| Completed |
NCT05999266 -
The Cartilage and Muscle Thickness on Knee Pain in Patients With Rheumatoid Arthritis
|
||
| Recruiting |
NCT05302934 -
Evaluation of the PHENO4U Data Platform in Patients Undergoing Total Knee Arthroplasty
|
||
| Recruiting |
NCT04169100 -
Novel Form of Acquired Long QT Syndrome
|
Phase 4 |