A Study to Evaluate the RNA Signature of Rheumatoid Arthritis From Synovium and Whole Blood

Rheumatoid Arthritis Clinical Trial

Official title: A Study to Evaluate the RNA Signature of Rheumatoid Arthritis From Synovium and Whole Blood

Status Terminated

Clinical Trial Summary

Rheumatoid arthritis is a systemic disease, it is not clear whether the gene expression profile exhibited by circulated peripheral blood cells and that expressed by the inflamed synovium mirror one another. Understanding this relationship would be useful not only in potentially having a relatively non-invasive means to predict response to therapy but it might be useful in better understanding differences in RA expression amongst patients with this disease, thus perhaps assisting in target identification through a better understanding of disease processes.

Clinical Trial Description

Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease affecting approximately 1% of the adult population. The disease is characterised by inflammation of synovial tissue (ST) in multiple joints, which often leads to destruction of joint integrity, contributing to serious functional impairment and disability. The contributors to its pathology include joint inflammation, abnormal cellular and humoral responses, and synovial hyperplasia. Ultrasonography is a powerful, non-invasive, and feasible way to evaluate synovial hyperplasia and guide its collection by biopsy. ;

Related Conditions & MeSH terms

• Arthritis
• Arthritis, Rheumatoid
• Rheumatoid Arthritis

• NCT number: NCT00781469
• Study type: Observational
• Source: Imperial College London
• Status: Terminated
• Start date: November 2008
• Completion date: October 2010