Rheumatoid Arthritis Clinical Trial
Official title:
Multicenter, Prospective Study, on the Consequences of Anti-interleukin 6 Immunotherapy Treatment for Rheumatoid Arthritis on: - Healthy and Pathological Periodontium - The Level of Expression of Some Markers of Inflammation and Periodontal Pathogenic Bacteria in Periodontal Sulci and Periodontal Pockets
Rheumatoid arthritis and periodontitis are two inflammatory diseases that share many
pathophysiological similarities as some inflammatory mediators like TNF-alpha, IL-1, Il-6,
Il-17, Il-12 et Il-17, RANK-L, or OPG The most severe or progressive forms of rheumatoid
arthritis require in 10-30% of cases, the use of biotherapies such as anti-TNF-alpha, anti
CD-20 and anti-lL-6. All these treatments results in, among other things, an increased risk
of infection, both viral and bacterial.
These new biotherapies could have an impact on periodontal status
- either by favouring sub gingival colonization of root surfaces by periodontal
pathogenic bacteria and initiate periodontitis or exacerbate pre-existing
periodontitis,
- or a positive modulation of the host response by inhibiting bone resorption of the
alveolar process.
To date, very few studies have been conducted on this subject which is really a
translational research, involving several medical specialties.
n/a
Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
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