Clinical Trials Logo

Clinical Trial Summary

To investigate the effect of CTLA4-Ig (abatacept) on phenotype, transcriptional profile, B cell receptor usage and functional parameters of circulating B cells expressing anticitrullinated protein antibodies (ACPA) in patients with early, methotrexate-naïve, ACPA positive rheumatoid arthritis.


Clinical Trial Description

B cells expressing anti citrullinated protein antibodies (ACPA) in patients with rheumatoid arthritis (RA) display an activated, proliferative phenotype. Experimental data indicate that ACPA and ACPA-expressing B cells are actively involved in driving the disease process in RA. The present study is based on the hypothesis that targeted intervention with CTLA4-Ig (abatacept) as a means to interfere with T cell help for B cells in early, active, ACPA-positive rheumatoid arthritis can reverse the activated, proliferative phenotype of citrullinated antigen-specific B cells. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03492658
Study type Interventional
Source Leiden University Medical Center
Contact Nienke Blomberg
Phone +31 (0) 715298733
Email n.j.blomberg@lumc.nl
Status Not yet recruiting
Phase Phase 4
Start date May 2018
Completion date September 2021

See also
  Status Clinical Trial Phase
Completed NCT02833350 - Safety and Efficacy Study of GDC-0853 Compared With Placebo and Adalimumab in Participants With Rheumatoid Arthritis (RA) Phase 2
Completed NCT01076205 - Safety and Effect on Quality of Life/Work Productivity of Humira in Patients With Rheumatoid Arthritis N/A
Enrolling by invitation NCT03248518 - Lessening the Impact of Fatigue in Inflammatory Rheumatic Diseases N/A
Enrolling by invitation NCT03514355 - MBSR in Rheumatoid Arthritis Patients With Controlled Disease But Persistent Depressive Symptoms N/A
Completed NCT02037737 - Impact and Use of Abatacept IV for Rheumatoid Arthritis in Real Life Setting N/A
Recruiting NCT01087125 - Abatacept Pregnancy Exposure Registry
Recruiting NCT03690466 - Ultrasound Treatment of Rheumatoid Arthritis N/A
Recruiting NCT03312465 - Anatomical Shoulder Domelock System Study N/A
Recruiting NCT01942174 - VACcination In Methotrexate Treated Rheumatoid Arthritis Patients Phase 3
Completed NCT02139345 - TC-A Registration Study N/A
Recruiting NCT03699293 - NSAIDs vs. Coxibs in the Presence of Aspirin Phase 4
Active, not recruiting NCT02648035 - EMBRACE-SC: Observational Study of Subcutaneous (SC) Tocilizumab Alone or in Combination With Conventional Disease-Modifying Antirheumatic Drugs (cDMARDs) in Rheumatoid Arthritis
Completed NCT00069342 - Health Beliefs and Health Behaviors Among Minorities With Rheumatic Diseases
Completed NCT02885181 - Safety, Tolerability, and Efficacy of GS-9876 in Participants With Active Rheumatoid Arthritis on Background Therapy With Methotrexate Phase 2
Not yet recruiting NCT03061877 - Anxiety Depression and Rheumatoid Arthritis
Not yet recruiting NCT03421184 - Dietary Phytoestrogens as Risk Factors for Systemic Lupus Erythematosus N/A
Not yet recruiting NCT03254966 - Study of SHR0302 Tablets (SHR0302) as Monotherapy in Active Rheumatoid Arthritis (RA) Patients Phase 2
Recruiting NCT02897011 - 2-week dc of MTX and Influenza Vaccination in RA N/A
Recruiting NCT02820038 - Enhancing Patient Ability to Understand and Utilize Complex Information Concerning Medication Self-management N/A
Recruiting NCT02666443 - Low Dose Dexamethasone in Supraclavicular Blocks N/A