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NCT04441736 Clinical Trial

Post -Extubation Respiratory Failure

Respiratory Insufficiency Clinical Trial

Official title:
Different Oxygenation Modalities for Early Post Extubation Failure

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT04441736
Other study ID # MS-313-2019
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date February 20, 2019
Est. completion date May 31, 2020

Study information
Verified date May 2024
Source Cairo University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

comparing high flow nasal cannula , conventional oxygen tharapy and non invasive ventilation post-extubation period for patients mechanically ventilated due to respiratory failure regarding re-intubation rate, ICU outcome & 28 days mortality

Description:

patients with respiratory failure either type I or type II planned for extubation will be divided into 3 groups post extubation : Group I: will receive high flow nasal cannula giving oxygen 60 litres / minute flow group II: will receive nasal cannula up to 10 litres / minute group III: will receive non invasive ventilation Data of the patients will be collected for 28 days post-extubation and analysed

Recruitment information / eligibility
Status Completed
Enrollment 60
Est. completion date May 31, 2020
Est. primary completion date May 30, 2020
Accepts healthy volunteers No
Gender All
Age group 18 Years to 80 Years
Eligibility Inclusion Criteria: - respiratory failure type I and Type II Exclusion Criteria: - Mechanical ventilation due to other cause such as disturbed conscious level or respiratory muscle weakness

Study Design

Related Conditions & MeSH terms

Intervention

Device:
• High flow nasal cannula
Device gives high flow oxygen comparable to non invasive ventilation and conventional oxygen therapy

Locations
Country Name City State
Egypt Faculty of Medicine Giza

Sponsors (1)
Lead Sponsor Collaborator
Cairo University

Country where clinical trial is conducted

Egypt, 

Outcome
Type Measure Description Time frame Safety issue
Primary Number of participants with post extubation respiratory failure Number of participants with post extubation hypoxemia with or without hypercapnea 7 days
Secondary Rate of ICU stay and mortality Duration of ICU stay and incidence of mortality 28 days
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Completed NCT04115969 - Outcome After Non-invasive Ventilation.