Respiratory Distress Syndrome, Adult Clinical Trial
Official title:
Effects of Positive End-expiratory Pressure and Tidal Volume on Fluid Responsiveness of Acute Respiratory Distress Syndrome.
Verified date | November 2012 |
Source | Chang Gung Memorial Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Fluid responsiveness (FR)refers to the ability of heart to increase its stroke volume in response to volume load.Low tidal volume and high PEEP exerts contrast effect on the prediction of fluid responsiveness, the aim of this study is to compare the relative predicting power of the dynamic preload indicator (PPV, SVV), passive leg raising test, and pleth variability index (PVI) on the fluid responsiveness of acute respiratory distress syndrome ventilated with various PEEP levels or various tidal volumes.
Status | Unknown status |
Enrollment | 30 |
Est. completion date | |
Est. primary completion date | July 2014 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: Clinical signs of inadequate tissue perfusion were defined 1. systolic blood pressure< 9 mmHg(or a decrease > 50 mmHg in previously hypertensive patients) 2. need of vasopressive drugs(dopamine > 5 ug/Kg/min or norepinephrine) 3. urine output<0.5 mL/Kg/hr for at least 2 hrs 4. tachycardia (heart rate >100/min) 5. presence of skin mottling. Exclusion Criteria: 1. patient with spontaneous respiratory activity 2. cardiac arrhythmia 3. known intracardiac shunt 4. contraindication for passive leg raising(PLR),e.g.,pelvic trauma 5. unstable spine injuries or leg amputation 6. hemodynamic instability during the procedure,defined by a variation in heart rate or blood pressure of>10%over the 15-min period before starting the protocol 7. Patients of renal failure necessitate renal replacement therapy will be excluded also. |
Country | Name | City | State |
---|---|---|---|
Taiwan | Chang Gung Memorial Hospital | Taipei |
Lead Sponsor | Collaborator |
---|---|
Chang Gung Memorial Hospital |
Taiwan,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | increase of cardiac output after volume expansion | Patients are classified to be volume expansion responders or nonresponders according to whether the volume expansion induced cardiac index increase at the end of hydroxyethyl starch infusion is ?15% or < 15% of baseline cardiac index. | 4 hours |
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