Clinical Trials Logo

Clinical Trial Summary

The purpose of this study is to find out the possible relationship among TWEAK/Fn14, JAK/STAT3 and IDO as well as their roles in the dysfunction of immune micro-environment of endometrium in people diagnosed as repeated implantation failure after in vitro Fertilization-embryo transfer(IVF-ET).

We will use the technology of Western-blot and Immunohistochemistry to find out the relationship of the expression of TWEAK/Fn14, JAK/STAT3 and IDO in endometrium . Also, we will use technology of Western-blot and Immunohistochemistry to determine whether there are differences of the the expression of TWEAK/Fn14, JAK/STAT3 and IDO in endometrium between RIF group and control group.


Clinical Trial Description

The purpose of this study is to find out the possible relationship among TWEAK/Fn14, JAK/STAT3 and IDO as well as their roles in the dysfunction of immune micro-environment of endometrium in people diagnosed as repeated implantation failure after in vitro Fertilization-embryo transfer(IVF-ET).

We will use the technology of Western-blot and Immunohistochemistry to find out the relationship of the expression of TWEAK/Fn14, JAK/STAT3 and IDO in endometrium . Also, we will use technology of Western-blot and Immunohistochemistry to determine whether there are differences of the the expression of TWEAK/Fn14, JAK/STAT3 and IDO in endometrium between RIF group and control group. ;


Study Design

Time Perspective: Cross-Sectional


Related Conditions & MeSH terms


NCT number NCT02967419
Study type Observational
Source Tongji Hospital
Contact Zhang Tao, MD
Phone 13349963005
Email 584605743@qq.com
Status Not yet recruiting
Phase N/A
Start date January 2017
Completion date March 2018

See also
  Status Clinical Trial Phase
Not yet recruiting NCT01933893 - Follicular Versus Luteal Pipelle in Repeated Implantation Failure Patients N/A
Recruiting NCT04497558 - The Clinical Efficiency of Tb-ERA in Chinese RIF Patients N/A
Recruiting NCT04867759 - Uterine Natural Killer (uNK) Cell Expression in Patients With Repeated ICSI Failures: A Multicenter Cohort Study
Completed NCT01493440 - Atosiban Improves Implantation and Pregnancy Rates in Patients With Repeated Implantation Failure N/A
Not yet recruiting NCT02893722 - A Randomized Double Blind Comparison of Atosiban in Patients With RIF Undergoing IVF Treatment Phase 1
Completed NCT03405883 - Uterine Microbiome in Women With Repeated Implantation Failure and Normal Fertile Women
Completed NCT03445910 - Intrauterine Injection of Human Chorionic Gonadotrophin and Pregnancy Rate in ICSI N/A
Completed NCT04698109 - Establishment of the Human Intestinal and Salivary Microbiota Biobank - Gynecological Diseases
Recruiting NCT04533295 - The Effect of Acupuncture on IVF Pregnancy Outcomes for Women With RIF N/A