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Impact of Low Protein Diet Supplemented With Ketoanalogues Supplementation on Uremic Toxins Production — KETO-GUT  

Renal Failure Clinical Trial

Official title:
Impact of Low Protein Diet Supplemented With Ketoanalogues on Uremic Toxins Production and Glucose Metabolism in Chronic Kidney Disease

Clinical Trial Summary

Chronic kidney disease (CKD) is associated with accumulation of uremic toxins like p-cresyl sulfate and indoxyl sulfate that are associated of cardiovascular complication and perturbation of glucose metabolism. These toxins are produced by fermentation of protein by intestinal microbiota but the role of low protein diet and ketoanalogue supplementation on uremic toxins production and microbiota composition are unknown. Low protein diet supplemented with ketoanalogues is recommended inCKD patients to prevent progression of renal disease. The aim of this study is to determine the impact of uremic toxins concentration, microbiota composition and gut hormone involved in carbohydrate metabolism ( GLP-1, FGF19, bile acids) with low protein diet supplemented with ketoanalogues.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03959228
Study type Interventional
Source Hospices Civils de Lyon
Contact Laetitia KOPPE, MD
Phone +33 4 72 67 87 15
Email Laetitia.koppe@chu-lyon.fr
Status Recruiting
Phase Phase 3
Start date November 12, 2019
Completion date December 12, 2023
View Details
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