Establish a National Registry of REM Sleep Behavior Disorder

REM Sleep Behavior Disorder Clinical Trial

Official title: Establish a National Registry to Search for the Risk Factors, Etiology, and Neurodegenerative Progression of REM Sleep Behavior Disorder

Status Recruiting

Clinical Trial Summary

In this proposed study, the investigators aim to build up a large cohort of Rapid eye movement sleep behavior disorder (RBD) to study the etiology and risk factors of neurodegeneration.

Clinical Trial Description

REM sleep behavior disorder (RBD) is a parasomnia characterized by abnormal behavioral manifestations during REM sleep. Accumulating evidence suggests that RBD is implicated as an integral part of disease progress of α-synucleinopathy neurodegeneration, such as Parkinson's disease (PD) and dementia with Lewy bodies.Previous studies have identified a series of neurocognitive, autonomic, clinical and neurobiological markers for neurodegeneration in iRBD, such as olfactory dysfunction, color vision deficit, autonomic dysfunction, tonic EMG activity during REM sleep, and psychiatric disorder. However, the prevalence rate of RBD was relatively low and most of the RBD studies only have 100 or below cases. and there might be ethic differences in RBD which indicates that the findings from western countries might not be applicable to Chinese. In these regards, the investigators aimed to build up a large cohort of Rapid eye movement sleep behavior disorder (RBD) to study the etiology and risk factors of neurodegeneration. ;

Related Conditions & MeSH terms

• Mental Disorders
• REM Sleep Behavior Disorder

• NCT number: NCT03671798
• Study type: Observational
• Source: Chinese University of Hong Kong
• Contact: Jihui Zhang, PhD
• Phone: (852) 39197647
• Email: jihui.zhang@cuhk.edu.hk
• Status: Recruiting
• Start date: October 2014
• Completion date: April 2022