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Regional Anesthesia clinical trials

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NCT ID: NCT03618459 Completed - Regional Anesthesia Clinical Trials

Post-discharge Pain After Breast-surgery Treated by Paravertebral Block

Start date: January 1, 2016
Study type: Observational

Breast surgery is known being associated to a high risk of persistent post-operative pain, which has been related, among other factors, to a poorly treated acute pain. Paravertebral block has been successfully employed for anesthesia and analgesia after breast surgery, however its impact on persistent post-operative pain has rarely been investigated. Aim of this study is to assess prevalence, characteristics and consequences of post-discharge pain and its correlation to the incidence of persistent post-operative pain development in a continuous cohort of patients undergoing breast surgery with a paravertebral block. Investigators designed a prospective, observational study on a continuous cohort of adult patients undergoing breast surgery with a standardized thoracic paravertebral block performed before general anesthesia induction. Patients were subsequently interviewed 6 months after hospital discharge in order to assess the incidence, features and duration of post-discharge pain.

NCT ID: NCT03500744 Not yet recruiting - Hysterectomy Clinical Trials

Erector Spinae Plane Block for Major Gynecologic and Urologic Surgery

Start date: July 1, 2018
Phase: Phase 2/Phase 3
Study type: Interventional

Regional anesthesia, also know as a nerve block, is a key component of pain control after major abdominal surgery. Bilateral erector spinae plane block (ESPB) performed at low thoracic level has been shown to be an effective pain control method in case reports. This pilot study aims to further characterize the pain-control characteristics and to provide baseline data for future trials.

NCT ID: NCT03450096 Recruiting - Pain, Postoperative Clinical Trials

Continous Lumbar Plexus Block in Children

Start date: June 5, 2018
Phase: N/A
Study type: Interventional

Randomised controlled prospective trial with 2 groups (active group with Lumbar plexus block (LPB)-catheter vs control group). In a randomized controlled trial, the investigators will investigate under controlled circumstances the effect of a LPB-catheter placed with ultrasound guided "Shamrock"-technique to improve postoperative pain treatment after unilateral open hip and femoral surgery in paediatric patients. The investigators will investigate the effect on opioid consumption and the reduction of opioid related side effects during the first 24 postoperative hours

NCT ID: NCT03442036 Enrolling by invitation - Regional Anesthesia Clinical Trials

Comparing Through-the-Needle With Suture-Method Catheter Designs for Popliteal Nerve Blocks

Start date: April 6, 2018
Phase: N/A
Study type: Interventional

Following painful surgical procedures, postoperative analgesia is often provided with a single-injection peripheral nerve block. Hothe investigatorsver, even with the longest-acting FDA-approved local anesthetic currently available-bupivacaine-the block duration is measured in hours, while the surgical pain may persist for days. A continuous peripheral nerve block allows a prolonged block, consisting of a percutaneously-inserted catheter with its orifice adjacent to a target nerve/plexus through which local anesthetic may be administered. Two basic perineural catheter designs currently exist: (1) catheters that are inserted either through or over a straight hollow-bore needle; and, (2) catheters that are attached to the back of a hollow suture-shaped needle that pulls the catheter adjacent to the target nerve ("suture-method" design). To date, a comparison of the relative risks and benefits of these two designs have not been investigated. The investigators therefore propose a randomized, observer-masked, controlled, parallel-arm, clinical trial to compare these two catheter designs when used to provide post-surgical analgesia following foot and ankle surgery.

NCT ID: NCT03431532 Completed - General Anesthesia Clinical Trials

Monocyte Subsets Altered by Anesthesia

Start date: February 1, 2013
Phase: N/A
Study type: Observational [Patient Registry]

The impact of different anesthetic techniques on the immune system remains unclear. Aim of this ex vivo / in vitro study was to determine the effects of general and neuraxial anesthesia on monocyte subset alteration and the release of prototypical pro- and anti-inflammatory cytokines. Twenty patients undergoing total knee replacement surgery were randomly assigned to receive either general anesthesia (ITN) or combined spinal/epidural anesthesia (CSE). CD14 and HLA-DR expression patterns on monocytes and intracellular TNF-alpha production were quantified via flow cytometry. TNF-α and IL-10 release were measured via enzyme linked immunosorbent assay (ELISA).

NCT ID: NCT03419117 Not yet recruiting - Pain, Postoperative Clinical Trials

Analgesic Efficacy of Single-shot Erector Spinae Block for Thoracic Surgery

Start date: July 1, 2018
Phase: N/A
Study type: Interventional

The erector spinae plane (ESP) block is a novel regional anesthetic technique for the treatment of thoracic, cervical, and abdominal pain. This pilot study aims to investigate the post-operative analgesic effectiveness of ultrasound guided single-shot ESP blocks for patients undergoing minimally invasive thoracoscopic wedge resections of the lung in comparison to those receiving conventional parental opioid analgesia alone. This will be achieved through the use of objective measures including quality the 40 point Quality of Recovery assessment (QoR-40) on postoperative day (POD) 1, visual-analogue pain scale (VAS) in the post-anesthetic care unit (PACU) and at POD 1, and oral morphine-equivalent (OME) opioid consumption in the PACU and at 24 hours post-operatively.

NCT ID: NCT03377764 Terminated - Regional Anesthesia Clinical Trials

Spinal Anesthesia in Patients With Poorly-palpable Surface Landmarks

Start date: August 2011
Phase: N/A
Study type: Observational

Anesthesia trainees can perform spinal anesthesia in patients who have poorly-palpable surface landmarks with fewer needle passes using an ultrasound-guided technique compared to the conventional surface landmark-guided technique.

NCT ID: NCT03277391 Recruiting - Post-operative Pain Clinical Trials

Serratus Anterior Plane Block: Post-operative Analgesia in Video-assisted Thoracic Surgery

Start date: April 14, 2017
Phase: N/A
Study type: Interventional

The objective of the study is to compare the efficacy of the Serratus Anterior Plane block (SPB) realised in its deep plane, with a multi-holed catheter in place for twenty four hours, to a standard intravenous analgesia for small videoassisted thoracic surgery interventions. The objective is also to evaluate the resorption rate of local anesthetic at this level, and make a population pharmacokinetic analysis.

NCT ID: NCT03193658 Not yet recruiting - Regional Anesthesia Clinical Trials

USG Thoracolumbar Interfascial Plane (TLIP) in Lumbar Spine Surgeries

Start date: August 1, 2017
Phase: N/A
Study type: Interventional

The study aims to evaluate the effect of US guided bilateral Thoracolumbar Interfascial plane (TLIP) block performed at the level of the lumbar spine surgery (involving 1 up to 3 adjacent lumbar vertebrae) after induction of general anesthesia and before starting the surgery on postoperative opioid consumption by the patients during the first 24 hours postoperative.

NCT ID: NCT03117894 Recruiting - Anesthesia Clinical Trials

PECS-2 for Breast Surgery

Start date: May 23, 2017
Phase: N/A
Study type: Interventional

There is no consensus regarding which alternative is the best anesthesia for breast surgery, general anesthesia and morphine for postoperative analgesia or a combination of regional anesthesia and general anesthesia that possibly attenuates or abolishes the need for morphine. The current study aims to determine which of the two strategies that is best in relation to postoperative pain, nausea and risk of recurrence of the disease.