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Study of Safety and Tolerability of VLX600, an Iron Chelator, in Patients With Refractory Advanced Solid Tumors

Refractory Cancer Clinical Trial

Official title:
A Phase I Study of the Safety and Tolerability of VLX600, an Iron Chelator, in Patients With Refractory Advanced Solid Tumors

Clinical Trial Summary

The purpose of this study is to evaluate the safety and tolerability of the investigational drug VLX600 in patients with refractory advanced solid tumors.

Clinical Trial Description

This Phase I, open label dose escalation study of VLX600 in patients with refractory advanced solid tumors will determine the safety profile and maximum tolerated dose (MTD) of VLX600 when administered by intravenous infusion on Days 1, 8, and 15 of each 28-day treatment cycle. Dose escalation will proceed according to the standard "3 + 3" design using doubling doses. The doses are: 10, 20, 40, 80, 160, and 210 mg VLX600. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02222363
Study type Interventional
Source Vivolux AB
Contact
Status Terminated
Phase Phase 1
Start date February 18, 2015
Completion date December 28, 2016
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