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Reflux Oesophagitis clinical trials

View clinical trials related to Reflux Oesophagitis.

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NCT ID: NCT01599858 Completed - Reflux Oesophagitis Clinical Trials

Effect of Repeated Doses of YF476, Omeprazole and Placebo on Stomach Acidity in Healthy Volunteers

Start date: August 1996
Phase: Phase 1
Study type: Interventional

The objectives of this study were: To compare repeated doses of YF476 at 2 dose levels, placebo and omeprazole with respect to their effect on basal- and food- stimulated gastric pH in healthy volunteers. To compare repeated doses of YF476 at 2 dose levels, placebo and omeprazole with respect to their effect on basal and meal stimulated pH. To assess the safety, tolerability and pharmacokinetics of repeated doses of YF476 in healthy volunteers.

NCT ID: NCT01597674 Completed - Reflux Oesophagitis Clinical Trials

Effect of 5, 10 or 25 mg of YF476 Daily for 14 Days on Stomach Acidity in Healthy Volunteers

Start date: April 1997
Phase: Phase 1
Study type: Interventional

The objective of the study was to assess whether the tolerance to the effect of YF476 on gastric pH observed with repeated doses in a previous study in healthy volunteers can be avoided by using smaller doses of YF476.

NCT ID: NCT01538797 Completed - Reflux Oesophagitis Clinical Trials

Effect of Single Doses of YF476 on Stomach Acidity Compared With Ranitidine and Placebo in Fasted and Fed States

Start date: July 1996
Phase: Phase 1
Study type: Interventional

The objectives of the study were: - To compare a single dose of YF476 at 3 dose levels, placebo and ranitidine with respect to their effects on basal- and food- stimulated gastric pH in healthy volunteers. - To assess whether there is a relationship between the pharmacokinetics of YF476 and gastric pH in healthy volunteers. - To assess the safety and tolerability of single doses of YF476 in healthy volunteers.

NCT ID: NCT01538784 Completed - Reflux Oesophagitis Clinical Trials

Safety, Tolerability and Pharmacokinetics of Single Rising Doses of YF476, a Gastrin Antagonist, in Healthy Men

Start date: May 1996
Phase: Phase 1
Study type: Interventional

The objectives of the study were: - To assess the safety, tolerability and pharmacokinetics of YF476 in healthy volunteers. - To select a dose or doses of YF476 for detailed pharmacodynamic studies in healthy volunteers.