Clinical Trials Logo

Reduced Intensity Conditioning (RIC) clinical trials

View clinical trials related to Reduced Intensity Conditioning (RIC).

Filter by:
  • None
  • Page 1

NCT ID: NCT00682799 Completed - Clinical trials for Myelodysplastic Syndrome (MDS)

Serial Analysis of Chimerism in Patients With Refractory Cytopenia (RC) Transplanted With Reduced Intensity Conditioning (RIC)

Start date: April 2007
Phase: N/A
Study type: Observational

This is a prospective, non-randomized multi-center multi-national study to evaluate the chimerism measured by STR and SNP in patients with hypoplastic RC and normal karyotype transplanted with a preparative regimen of reduced intensity. Primary objectives: - To study hematopoietic chimerism in whole blood and different cell population (CD14, CD15, CD 56, CD3, CD19) as well as in dendritic cells and regulatory T-cells after SCT with RIC in patients with RC - To compare the results of chimerism obtained with standard STR PCR (sensitivity 1%) with those obtained with SNP PCR (sensitivity 0.1- 0.01%) Secondary objectives: - To evaluate the relationship between mixed chimerism and hematological engraftment, OS and EFS - To study the impact of mixed chimerism in plasmacytoid dendritic and regulatory T-cells on the incidence of acute and chronic GVHD