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Red Blood Cell Transfusion clinical trials

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NCT ID: NCT03344887 Not yet recruiting - Clinical trials for Red Blood Cell Transfusion

An Innovative Trial Assessing Donor Sex on Recipient Mortality

Start date: May 14, 2018
Phase: Phase 4
Study type: Interventional

The iTADS trial will test an important blood donor characteristic - donor sex - to see whether male donor blood leads to a greater benefit for transfusion recipients compared to female donor blood. The trial will help determine how the investigators can tailor the selection of blood donors based on donor characteristics (e.g. sex) to further improve the safety and optimize the clinical benefit of blood products in Canada.

NCT ID: NCT02566577 Completed - Clinical trials for Red Blood Cell Transfusion

Physiologic Effects of RBC Transfusion

Start date: July 2013
Phase: Phase 4
Study type: Interventional

The purpose of this study is to determine how red blood cell transfusions, particularly the length of storage time of units of packed red blood cells, affects the cardiovascular function in patients receiving transfusions. This study will also determine the most ideal way of storing and processing blood, and assess how transfusion affects a person's ability to exercise and how their blood vessels relax and contract.

NCT ID: NCT01258010 Completed - Orthopedic Surgery Clinical Trials

Impact of Tranexamic Acid on Red Blood Cell Transfusion in Spinal Surgery

Start date: April 2011
Phase: N/A
Study type: Interventional

Spinal surgery may be associated with substantial blood loss which often requires erythrocyte transfusion. Transfusion of red blood cells (RBC) is not free of adverse events and has been associated with increased risks of infection, and globally higher morbidity and mortality. Different techniques have been used to reduce perioperative blood losses and related transfusions. Tranexamic acid has been used successfully in cardiac and hepatic surgery. However, only a few studies have reported on the use of antifibrinolytic drugs in spinal surgery. This study was designed to assess the efficacy and safety of tranexamic acid in spinal surgery for the reduction of RBC transfusion. Hypothesis: the infusion of tranexamic acid during spinal surgery will reduce the risk of receiving a RBC transfusion and, in those patients transfused, reduce the number of blood products administered.