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Clinical Trial Summary

Recurrent pregnancy loss (RPL) defined as 3 or more pregnancy losses affects approximately 3% of couples trying to achieve parenthood. Most cases of RPL are unexplained and have no effective treatment to improve the chance of a live birth. Exciting indications for using Hydroxychloroquine (HCQ) include: Malaria profylaxis and treatment, systemic and discoid lupus erythematosus (SLE) and rheumatoid athritis (RA). HCQ has been reported to have the following properties (anti-thrombotic, vascular-protective, immunomodulatory, improving glucose tolerance, lipid-lowering, and anti-infectious).

There is no data concerning the benefit of HCQ in RPL. Administration for other indications provides extensive safety data during pregnancy.

This study has the potential to establish support for a new treatment option for unexplained RPL.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT03305263
Study type Interventional
Source Rigshospitalet, Denmark
Contact Henriette Svarre Nielsen, MD, DMSc
Phone +4535457515
Email henriette.svarre.nielsen@regionh.dk
Status Recruiting
Phase Phase 3
Start date January 25, 2018
Completion date January 2023

See also
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