Recurrent Implantation Failure (RIF) Clinical Trial
Official title:
The First Study to Compare the Effect of Freeze All Policy Versus Fresh Embryo Transfer After ICSI in Patients With Recurrent Implantation Failure
This is the first study to investigate, whether pregnancy and implantation rates would improve in patients with recurrent implantation failure (RIF), if all embryos were to be frozen and transferred in a consecutive natural cycle.
There is growing evidence that elective frozen-thawed embryo transfer in a non-stimulated
cycle (freeze-all policy) would eliminate the risk of controlled ovarian stimulation and
resulting in better endometrial receptivity and lower uterine contractility as compared with
fresh intracytoplasmic sperm injection (ICSI) cycles.
RIF refers to women who fail to achieve a clinical pregnancy, in a minimum of three embryo
transfer cycles with at least four good-quality embryos were transferred in a woman < 40
years. It affects approximately 10% of ICSI cases. Many management protocols aimed to enhance
ICSI outcome in cases of RIF, however, none of them examined the effect of freeze all policy
in this category of patients.
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