Clinical Trials Logo

Clinical Trial Summary

The aim of this study was to assess the clinical efficacy of the acellular porcine derived collagen matrix (PADM) in comparison with connective tissue graft (SCTG ) in the treatment of multiple adjacent gingival recessions (MAGR). The primary objectives of the study were to evaluate mean and complete roots coverage. Additionally, the secondary objective was to evaluate and compare the clinical effectiveness of PADM and SCTG for the treatment of MAGR defects applying modified coronally advanced tunnel technique (MCAT).


Clinical Trial Description

Treatment of multiple adjacent gingival recessions (MAGR) still presents a challenge for the clinician. The management of soft tissues becomes more complicated and the wound healing may be compromised by a variety of factors.

According to the available medical databases, predictable root coverage is possible for multiple-tooth recession defects using subepithelial connective tissue graft (SCTG) procedures. However, alternative materials to SCTG are supported by evidence of varying strength, with the need for additional research to confirm their performance and success rate. Because of that, the aim of this study was to assess the clinical efficacy of the acellular porcine derived collagen matrix (PADM) in comparison with connective tissue graft (SCTG ) in the treatment of multiple adjacent gingival recessions (MAGR).

This study is a randomised controlled clinical trial of 12 months duration. Sixteen patients with a total of 81 MAGR Miller's Class I or II were enrolled in this study. Recessions were randomly treated with PADM and SCTG, combined with a modified coronally advanced tunnel technique (MCAT). Several parameters, such as gingival recession coverage (RC), keratinized tissue width (KTW), keratinized tissue thickness (KTT) and clinical attachment level (CAL) were recorded at baseline and one year postoperatively. Healing index (HI) was registered on 1st, 2nd, and 3rd-week post-surgery in order to estimate healing events. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03163654
Study type Interventional
Source Botiss Medical AG
Contact
Status Completed
Phase N/A
Start date December 2014
Completion date September 2016

See also
  Status Clinical Trial Phase
Recruiting NCT05565079 - Root Coverage Using ADM and Coronally Positioned Tunnel With or Without Enamel Matrix Derivative Phase 4
Completed NCT03582995 - Root Coverage With Acellular Dermal Matrix and Bovine Derived Osseous N/A
Recruiting NCT05961566 - Palatal Volumetric Change Analysis Following Connective Tissue Graft With and Without Donor Site Augmentation N/A
Completed NCT04514055 - Connective Tissue Graft Wall Technique in Management of Cairo's RT2 and RT3 With Intra-bony Defects N/A
Enrolling by invitation NCT04202198 - Pinhole Surgical Technique for Root Coverage Using PRF Phase 2
Recruiting NCT06037161 - Comparison of Two Methods of Covering a Single Lower Front Tooth With Receded Gums N/A
Completed NCT03106506 - Influence of Connective Tissue Graft Around Implants N/A
Not yet recruiting NCT05949112 - Toothbrush in the Genesis and Prevention of Dental Recessions N/A
Completed NCT04016493 - Long-term Outcomes of Tunnel Technique
Completed NCT05342649 - Effect of Two Methods of Soft Tissue Augmentation for Socket Closure on Soft Tissue Landmarks and Ridge Dimensions N/A
Not yet recruiting NCT03802370 - Soft Tissue Augmentation Around Immediate Implants In The Esthetic Zone N/A
Not yet recruiting NCT05470660 - Coronally Advanced Flap With Alloderm Versus Coronally Advanced Flap With Micro-needling on RT1 Gingival Recession N/A
Enrolling by invitation NCT03660566 - Use of Leucocyte- and Platelet-rich Fibrin Membranes in Single Implant N/A
Enrolling by invitation NCT05947305 - Alternative Gingival De-Epithelialization Techniques N/A
Not yet recruiting NCT06166017 - Lingual Keratinized Tissue in Fully Edentulous Patients and Its Impact on Implant Health
Not yet recruiting NCT05823415 - Clinical Evaluation of Laterally Closed Tunnel Technique Versus Coronally Advanced Flap Combined With Connective Tissue Graft for the Treatment of Isolated RT2 Gingival Recession N/A
Active, not recruiting NCT03090906 - Soft Tissue Volume Gain and Stability Comparing Palate and Tuberosity N/A