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Safety and Immunogenicity of the Candidate Rabies Vaccine ChAdOx2 RabG

Rabies Clinical Trial

Official title:
A Phase I Clinical Trial to Determine the Safety and Immunogenicity of the Candidate Rabies Vaccine ChAdOx2 RabG in UK Healthy Adult Volunteer

Clinical Trial Summary

This is a first-in-human, open-label, dose escalation, phase I clinical trial to assess the safety and immunogenicity of the candidate ChAdOx2 RabG vaccine in healthy UK volunteers aged 18-65. The vaccine will be administered intramuscularly (IM).

Clinical Trial Description

Volunteers will be recruited and vaccinated at the Centre for Clinical Vaccinology and Tropical Medicine (CCVTM), Oxford. There will be 3 study groups and it is anticipated that a total of 12 volunteers will be enrolled. Staggered enrolment will apply between study groups and for the first three volunteers within each group. The study includes an optional extended follow-up period, lasting one month and starting one year after vaccination. Volunteers will receive a complete pre-exposure prophylactic course of an existing rabies vaccine, allowing study of the immunological memory (recall response) induced by ChAdOx2 RabG. A second optional element of the study is the collection of saliva samples at each visit for the study of shedding of EBV and CMV. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04162600
Study type Interventional
Source University of Oxford
Contact
Status Active, not recruiting
Phase Phase 1
Start date January 2, 2020
Completion date September 2023
View Details
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