Punctal Stenosis Clinical Trial
Official title:
Evaluation of Acquired Punctal Stenosis by Using Anterior Segment Optical Coherence Tomography (AS-OCT)
Purpose of the study
To evaluate the lower puntum dimensions in cases of acquired punctal stenosis(APS), using
anterior segment optical coherence tomography (AS-OCT).
(B)Examination:
1. External examination: should be done to rule out causes of watering other than punctal
stenosis (facial palsy, lacrimal pump failure, swelling in lacrimal sac area and regurge
test)
2. Slit lamp examination: for tear meniscus, lid margin, conjunctiva and punctual orifice
3. Fluorescein dye disappearance test: performed with a drop of 2% fluorescein in lower
conjunctival sac, patient is instructed not to wipe the eyes. After 5 minutes, presence
of staining in the tear film is assessed with cobalt blue filter.
4. Probing and lacrimal syringing, if patent confirms punctal stenosis to be the cause of
epiphora rather than block in the lower lacrimal drainage system.
5. Anterior segment optical coherence tomography examination (AS-OCT) for the lower
punctum: measuring the outer puntcal diametre, inner punctal diameter and punctal depth.
Examination of the lower punctum was performed using Spectral Domain OCT machine; RTVue
model-RT100 CAM system (Optovue Inc., Fremont, CA, USA) version 6.2, by attaching the
cornea/anterior module lens (CAM). CAM lens has a wide-angle, high-magnification lens of 10
mm working distance. The axial resolution was 5 μm, and the lateral resolution was 8 μm. The
scan beam has wavelength of 840 ± 10 nm. The two red external illumination (light emitting
diode ) LED on headrest were approximated on each side of the lower punctum for proper
illumination and imaging of the punctum. Gentle eversion of the medial part of the lower lid
was performed to expose the lower lid punctum, so the vertical canaliculus was brought to be
at an axial plain without undue stretching or pressure to the lower lid. Line scan was the
used examination scan, containing 1020 A-scans/line, and is 8mm in length.
Measurements of the external punctal diameter, internal punctal diameter, and punctal depth
were performed on the B-scan image of the lower punctum (by selecting it from the Review
window), using distance measurement tool. External punctal diameter was measured as a line
connecting highest points on the medial and lateral punctal walls. Internal punctal diameter
was measured as a horizontal line just above the narrowing. The distance between the line
representing the external punctal diameter and the floor of the punctum was calculated and
referred to the punctal depth
Results:
Data wil be collected and statistically analysed
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT04624022 -
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||
| Completed |
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N/A |