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Clinical Trial Summary

To evaluate the safety and efficacy of first-line combination therapy using riociguat with ambrisentan in patients with Pulmonary Arterial Hypertension (PAH).


Clinical Trial Description

This is a prospective, multi-center, open-label, exploratory study with patients followed for a period of one year. The treatment duration period in this study begins at the initiation of ambrisentan plus riociguat and will continue for 12 months. Patients will come to clinic for a visit at month 4 and 12. Assessments will include Right Heart Catheterization, 6 Minute walk test, cardiac MRI, questionnaires and nt-Pro-BNP. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03809156
Study type Interventional
Source University of Calgary
Contact Naushad Hirani, MD
Phone 403 943 4759
Status Recruiting
Phase Phase 4
Start date April 26, 2016
Completion date January 31, 2021

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