Pulmonary Edema Clinical Trial
Official title:
Continuous Positive Airway Pressure Versus Non-Invasive Positive Pressure Support Ventilation in Acute Cardiogenic Pulmonary Oedema: a Prospective Randomised Multicentre Trial.
To assess the intubation rate in patients affected by severe cardiogenic pulmonary edema treated with CPAP or NPPV.
Background Although non-invasive ventilation has shown to be an effective treatment for
acute cardiogenic pulmonary oedema (ACPO), literature still lacks of multi-centre randomised
prospective studies that compares CPAP with NPPV.
Aim of the study was to assess efficacy and safety of CPAP and NPPV in patients with ACPO.
Methods 80 patients with ACPO were randomly assigned to receive CPAP or NPPV (40 for each
group) through a face mask.
Inclusion criteria were: severe dyspnoea, respiratory rate > 30, PaO2/FiO2 < 200, muscle
fatigue.
Main end-points were endotracheal intubation, length of ventilation, hospital length of stay
and mortality.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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