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Study of Lung Function in Children Who Have Undergone Bone Marrow Transplantation

Pulmonary Complications Clinical Trial

Official title:
The Impact of Pediatric Marrow Transplantation on Late Pulmonary Function

Clinical Trial Summary

RATIONALE: Assessing the long-term effects of bone marrow transplant on lung function in patients may improve the ability to plan treatment.

PURPOSE: This clinical trial studies lung function in pediatric patients who have undergone bone marrow transplant.

Clinical Trial Description

OBJECTIVES:

- Determine the delayed effects of bone marrow transplantation preparative regimens on pulmonary function in children surviving at least 5 years after transplantation for hematologic malignancy.

- Determine the relationship between pulmonary function and growth rates in these patients.

- Determine the effect of growth hormone treatment on pulmonary function in these patients.

- Determine the relationship between pulmonary function and age at time of transplantation in these patients.

- Determine the incidence and severity of restrictive pulmonary disease, and whether these factors vary with increasing time after transplantation in these patients.

OUTLINE: Patients undergo respiratory history, signs and symptoms assessment, pulmonary function tests (PFT) including spirometry, lung volumes, and diffusion, oxygen saturation by pulse oximetry, and height measurement.

Patients are assessed at 5-10 years, 10-15 years, and over 15 years after bone marrow transplantation. Patients with abnormal PFTs are assessed at more frequent intervals as clinically indicated.

PROJECTED ACCRUAL: Approximately 280 patients will be accrued for this study. ;

Study Design

N/A

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00009711
Study type Observational
Source Fred Hutchinson Cancer Research Center
Contact
Status Completed
Phase N/A
Start date March 1996
Completion date August 2005
View Details
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