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Clinical Trial Summary

Cardiopulmonary exercise testing is recommended for preoperative evaluation and risk stratification of lung resection candidates. Ventilatory efficiency (VE/VCO2 slope) has been shown to predict morbidity and mortality in lung resection candidates and has been shown superior to peak oxygen consumption (VO2). Patients with increased VE/VCO2 during exercise also exhibit increased VE/VCO2 ratio and decreased end-tidal CO2 at rest. Our first hypothesis is that rest ventilatory parameters predict morbidity and mortality in patients undergoing thoracic surgery. VE/VCO2 is well correlated with ventilation-perfusion mismatch, therefore it may be useful in hypoxemia prediction during one-lung ventilation during thoracic surgery. Our second hypothesis is that patients with high VE/VCO2 will be prone to hypoxemia development during one-lung ventilation.


Clinical Trial Description

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Study Design


Related Conditions & MeSH terms


NCT number NCT03498352
Study type Observational
Source St. Anne's University Hospital Brno, Czech Republic
Contact Ivan Cundrle, M.D., Ph.D.
Phone 00420543183533
Email Ivan.Cundrle@fnusa.cz
Status Recruiting
Phase
Start date September 1, 2017
Completion date December 31, 2021