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Clinical Trial Summary

Cardiopulmonary exercise testing is recommended for preoperative evaluation and risk stratification of lung resection candidates. Ventilatory efficiency (VE/VCO2 slope) has been shown to predict morbidity and mortality in lung resection candidates and has been shown superior to peak oxygen consumption (VO2). Patients with increased VE/VCO2 during exercise also exhibit increased VE/VCO2 ratio and decreased end-tidal CO2 at rest. Our first hypothesis is that rest ventilatory parameters predict morbidity and mortality in patients undergoing thoracic surgery. VE/VCO2 is well correlated with ventilation-perfusion mismatch, therefore it may be useful in hypoxemia prediction during one-lung ventilation during thoracic surgery. Our second hypothesis is that patients with high VE/VCO2 will be prone to hypoxemia development during one-lung ventilation.

Clinical Trial Description


Study Design

Related Conditions & MeSH terms

NCT number NCT03498352
Study type Observational
Source St. Anne's University Hospital Brno, Czech Republic
Contact Ivan Cundrle, M.D., Ph.D.
Phone 00420543183533
Status Recruiting
Start date September 1, 2017
Completion date December 31, 2021