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Pilot Study of the Safety and Efficacy of Carvedilol in Pulmonary Arterial Hypertension

Pulmonary Arterial Hypertension Clinical Trial

Official title:
Pilot Study of the Safety and Efficacy of Carvedilol in Pulmonary Arterial Hypertension

Clinical Trial Summary

The purpose of this study is to determine whether carvedilol treatment of patients with pulmonary arterial hypertension and associated right heart failure is safe and results in an improved function of the right heart.

Clinical Trial Description

Patients with pulmonary arterial hypertension (PAH) will be treated with carvedilol for 24 weeks. During this time, carvedilol will be titrated from an initial dose of 3.125mg BID to a maximal dose of 25mg BID. At the start and end of the study, we will obtain cardiac MRI, 6 minute walk distance, brain natriuretic peptide (serum), echocardiogram, and functional class assessment. Our primary outcome is a change in right ventricular ejection fraction with cardiac MRI. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00964678
Study type Interventional
Source Virginia Commonwealth University
Contact
Status Completed
Phase Phase 1/Phase 2
Start date June 2010
Completion date May 2014
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