Prostate Cancer Clinical Trial
Official title:
Combined, Intensified and Modulated Adjuvant Therapy in Prostate Carcinoma: a Phase II Trial
Patients with high risk prostate cancer may benefit from radiotherapy after radical prostatectomy. The investigators postulated that adjuvant androgen deprivation therapy (ADT), radiation dose escalation, and selective pelvic irradiation may improve outcome. A phase II trial was designed to prove that combined-intensified-modulated-adjuvant (CIMA) treatment may improve 5-year biochemical relapse free survival (bRFS) from 75% to 90% in high risk patients. The delivered dose to tumor bed and pelvic nodes was 64.8-70.2 Gy and 45 Gy (57% of patients), respectively, and 69% received ADT.
Prostate cancer patients at high risk of loco-regional recurrences may benefit from
postoperative radiotherapy (RT) following radical prostatectomy (EORTC trial 22911). However,
despite an improvement in biochemical relapse-free survival (bRFS), the risk of recurrences
remained high for those patients. The investigators postulated that adjuvant androgen
deprivation therapy (ADT), radiation dose escalation, and selective pelvic irradiation for
patients at risk for regional failures may improve the outcome. The
combined-intensified-modulated-adjuvant (CIMA) as described may improve survival through a
reduction of loco-regional and systemic failures.
A phase II trial was designed to test the hypothesis that CIMA treatment may improve 5-year
bRFS by 15%. Patients less than 80 years old, with a histological diagnosis of prostate
adenocarcinoma without distant metastases, stage pT2-4 N0-1, no previous treatments and an
ECOG performance status of 0-2 were selected. All patients had at least one of these
pathologic features: extracapsular extension, positive surgical margins, or seminal vesicle
invasion. Radiation dose to the tumor bed ranged from 64.8 to 70.2 Gy. Pelvic lymph nodes
were treated to 45 Gy in selected patients at risk of regional failures (57%). Selected
patients at risk for distant metastases (69.1%) received hormonal therapy.
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