Prostate Cancer Clinical Trial
Official title:
Correlation Between SUV on 68Ga-HBED-CC-PSMA and Gleason Score in Prostate Cancer
Prostate cancer is the second leading cause of cancer death in North American men older than
50 years. Prostate specific membrane antigen (PSMA) is a unique membrane bound glycoprotein,
which is overexpressed manifold on prostate cancer cells and is well-characterized as an
imaging biomarker of prostate cancer. Positron emission tomography / computer tomography
(PET/CT) is a nuclear medicine procedure based on the measurement of positron emission from
radiolabeled tracer molecules. 68Ga-HBED-CC-PSMA (DKFZ-11) (abbreviated 68Ga-PSMA) is a
tracer for prostate cancer PET imaging. The strength of functional imaging methods is in
distinguishing tissues according to metabolism rather than structure. Studies have shown that
PET/CT imaging with 68Ga-PSMA can detect prostate cancer lesions with excellent contrast and
a high detection rate even when the level of prostate specific antigen is low.
Study Objectives:
The objective of this study is to evaluate if the patient-wide SUVmax on 68Ga-PSMA PET/CT in
locoregional and metastatic prostate cancer correlates with histopathologic Gleason score at
initial biopsy. It is hypothesized that SUVmax will correlate positively with Gleason score.
This is of interest because non-invasive risk stratification may be possible in the future.
This will be a single-site JGH-only open label study in which one (1) 68Ga-PSMA PET/CT will
be performed on study participants. A PET/CT scan takes 2-3 hours.
n/a
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