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Prostate Cancer clinical trials

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NCT ID: NCT03634579 Terminated - Prostate Cancer Clinical Trials

MRI Guided Prostate Cancer Focal Laser Ablation

Start date: June 1, 2018
Phase: N/A
Study type: Interventional

The study is a prospective, single-arm, non-randomized, unblinded trial to determine the safety and efficacy of MRI guided focal laser ablation of localized low and intermediate risk prostate cancer. All subjects meeting the inclusion exclusion criteria and are enrolled will undergo a MRI guided focal laser ablation procedure. The primary aim of the study is to study the safety and efficacy of the procedure.

NCT ID: NCT03227744 Terminated - Prostate Cancer Clinical Trials

A Pilot Study of Prostate Cancer-specific Anxiety in Active Surveillance

Start date: April 19, 2017
Phase: N/A
Study type: Interventional

This study is a clinical trial to determine whether a 12-week group therapy intervention for patients undergoing Active Surveillance for Prostate Cancer can relieve disease-related anxiety and improve quality of life and delay elective treatment of prostate cancer. The goal of the study is to further our understanding of anxiety in men who have been diagnosed with prostate cancer and are undergoing Active Surveillance. Men who have elected Active Surveillance for their management of prostate cancer are eligible to participate in this study. After signing informed consent, all participants will complete two brief questionnaires (The Memorial Anxiety Scale for Prostate Cancer [MAX-PC] and the General Anxiety and Depression Scale 7 [GAD-7] to measure their anxiety levels. If the participant scores above a certain number, they will be asked to participate in the study. Patients will be randomly assigned to either a control group, who will receive no treatment, but continue to follow up with their urologist to manage their prostate cancer as usual, or the treatment group. The treatment group will receive 12 one-hour group therapy sessions that will take place once a week for 12 weeks with a licensed psychologist free of charge. They will be instructed to follow up with their urologist as previously determined for their prostate cancer management. Patients in both groups will be monitored for anxiety completing three questionnaires, the MAX-PC and GAD-7 which they previously completed, and the Functional Assessment of Cancer Therapy - Prostate (FACT-P) during the 4th and 12th weeks of therapy. If patients require further therapy beyond the group treatment sessions, the investigators may refer them to a psychologist or psychiatrist for further treatment.

NCT ID: NCT03211052 Terminated - Prostate Cancer Clinical Trials

A Study of Neoadjuvant TAK-700 and Leuprorelin Acetate Followed by Surgery Versus Surgery Alone

NEPTUNE
Start date: February 18, 2013
Phase: Phase 2
Study type: Interventional

This study investigates neoadjuvant TAK-700 orteronel for 6 months prior to prostatectomy. The three year biochemical free survival is the primary endpoint. There are a number of 2nd endpoints such as pathological complete response rate, the need for adjuvant radiation therapy, use of post operative radiotherapy an the rate of positive margins at surgery. Translational endpoints include measuring tumoural and plasma testosterone as well as other androgens. Patients with untreated high risk and intermediate risk operable prostate cancer will be treated with TAK-700 (plus LHRH agonist) for 24 weeks prior to planned prostatectomy.

NCT ID: NCT02911922 Terminated - Prostate Cancer Clinical Trials

Randomized Trial of Image -Guided Stereotactic Radiation Therapy (IG-SRT) in Prostate Cancer

Start date: September 2016
Phase: N/A
Study type: Interventional

Patients with low-risk or favorable intermediate-risk prostate cancer as defined by 1.2016 NCCN criteria will be eligible to participate on this study.

NCT ID: NCT02840162 Terminated - Prostate Cancer Clinical Trials

Pre-Prostatectomy Celecoxib or Placebo

Start date: May 2001
Phase: Phase 2
Study type: Interventional

This study will seek to determine if the downstream effects of cyclooxygenase-2 (COX-2) inhibition suggested by preclinical systems occur in human prostate cancer. To answer this question, men who have chosen prostatectomy will be randomly assigned to preoperative treatment with celecoxib or placebo for four weeks. Carefully collected tumor, premalignant, and benign prostate tissue will then be examined for apoptosis, androgen receptor and prostaglandin E2 levels. Tumor COX-2 expression will be correlated with observed treatment effects. The data generated by this study will serve as a foundation for the development of COX-2 targeted therapies for prostate cancer, will provide preliminary evidence for larger scale clinical trials aimed at treatment and prevention of prostate cancer, and will validate current preclinical models used to study COX-2 in prostate cancer.

NCT ID: NCT02758132 Terminated - Prostate Cancer Clinical Trials

Denosumab Plus Enzalutamide, Abiraterone and Prednisone Compared to Denosumab Plus Enzalutamide Alone for Men With Castrate Resistant Prostate Cancer (CRPC) With Bone Metastases

Start date: July 2015
Phase: N/A
Study type: Interventional

This is a correlative study to characterize serum metabolites associated with bone deposition, growth and turnover in patients with newly diagnosed metastatic CRPC who are not currently receiving bone targeting agents.

NCT ID: NCT02694380 Terminated - Breast Cancer Clinical Trials

Measuring the Effect of Radiation Therapy on Patient Activity Levels

Start date: July 2015
Phase:
Study type: Observational

The goal of this study is to measure the effect of radiation therapy on the activity levels of patients. This will be achieved by tracking their activity levels during a treatment course of radiation therapy.

NCT ID: NCT02656615 Terminated - Prostate Cancer Clinical Trials

Abiraterone-Rechallenge Study for CRPC Patients

ABI-RE
Start date: January 2016
Phase: Phase 2
Study type: Interventional

To assess activity of abiraterone-re-challenge in patients with advanced prostate cancer and prior response to abiraterone.

NCT ID: NCT02582749 Terminated - Prostate Cancer Clinical Trials

Androgen Deprivation Therapy +/- Radium-223 Dichloride in Metastatic Prostate Cancer With Bone Metastases

Start date: April 2016
Phase: Phase 2
Study type: Interventional

Newly diagnosed metastatic prostate cancer subjects with bone metastases will be accrued to this stratified randomized 2-arm Phase II trial. Subjects will be randomized 1:2 to ADT or ADT with Radium-223 dichloride respectively.

NCT ID: NCT02564549 Terminated - Prostate Cancer Clinical Trials

MRI-Based Active Surveillance to Avoid the Risks of Serial Biopsies in Men With Low-Risk Prostate Ca

Start date: October 5, 2015
Phase: N/A
Study type: Interventional

Phase II non-inferiority randomized trial of annual systematic biopsies versus mpMRI and targeted biopsies for men with low risk prostate cancer on active surveillance with any volume Gleason's Score 6, but no prior MRI imaging of the prostate.