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Prostate Cancer clinical trials

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NCT ID: NCT03533946 Not yet recruiting - Prostate Cancer Clinical Trials

Rucaparib in Nonmetastatic prOstAte With BRCAness

ROAR
Start date: July 2018
Phase: Phase 2
Study type: Interventional

This is a single arm, open label, phase II trial to assess efficacy of rucaparib.

NCT ID: NCT03532308 Not yet recruiting - Prostate Cancer Clinical Trials

Nutrition and Prostate Cancer

Start date: September 2018
Phase: Phase 3
Study type: Interventional

The purpose of this study is to assess the efficacy of Fermented Soy vs. placebo in 72 adults with localized prostate cancer prior to radical prostatectomy.

NCT ID: NCT03531099 Not yet recruiting - Prostate Cancer Clinical Trials

Phase 3, Multicenter, Randomized Study, Evaluating the Efficacy and Tolerability of Focused HIFU (High Intensity Focused Ultrasound) Therapy Compared to Active Surveillance in Patients With Significant Low Risk Prostate Cancer

HIFUSA
Start date: July 1, 2018
Phase: Phase 3
Study type: Interventional

The percentage of malignant prostate tumors detected very early is constantly increasing and the number of well differentiated tumors, with small volume and low risk of progression increases. When a tumor of this type is identified, radical prostatectomy remains the reference treatment, but this treatment is not without side effects. Active surveillance is a strategy which aims at detecting an early development of the cancerous disease in order to propose curative treatment in a timely manner and thus improve specific survival. Patients are therefore re-evaluated each year by rectal examination, PSA (Prostate-Specific Antigen) assay. Active surveillance remains difficult to manage psychologically for both the patient and the practitioner, because of the lack of treatment on the one hand and a rate of non-curable cancers close to 50% when signs of progression trigger a radical treatment. The aim of the focal treatment HIFU (High Intensity Focused Ultrasound) is to destroy the cancer without causing side effects in contrast to radical treatments. It is in this sense that it is positioned both as an alternative to radical surgery and as an alternative to active surveillance.

NCT ID: NCT03529643 Not yet recruiting - Prostate Cancer Clinical Trials

Effect of Anesthetic Method on Optic Nerve Sheath Diameter in Patients Undergoing Robot-assisted Laparoscopic Prostatectomy

Start date: May 14, 2018
Phase: N/A
Study type: Interventional

The purpose of this study was to evaluate the effect of anesthetic method on the optic nerve sheath diameter in patients undergoing robot-assisted laparoscopic prostatectomy.

NCT ID: NCT03525288 Not yet recruiting - Prostate Cancer Clinical Trials

PSMA-PET Guided Radiotherapy

PSMA-PETgRT
Start date: May 15, 2018
Phase: Phase 2/Phase 3
Study type: Interventional

PSMA PET/CT has demonstrated higher sensitivity in detecting metastases than current imaging standard of care (CT and bone scan). [18F]DCFPyL is a promising high-sensitivity second generation PSMA-targeted urea-based PET probe. The hypothesis is that definitive radiotherapy (RT) informed by PSMA-PET findings will lead to improved cancer control outcomes compared to RT guided by conventional staging only. This study utilizes cmRCT design in companion to PERA (Partnership initiative for the Evaluation of technological innovation in Radiotherapy).

NCT ID: NCT03520478 Not yet recruiting - Prostate Cancer Clinical Trials

A Study of SHR3680 in Treating Patients With Hormone Sensitive Prostate Cancer

Start date: May 30, 2018
Phase: Phase 3
Study type: Interventional

The aim of this study is to compare the safety and efficacy of SHR3680 with bicalutamide in the treatment of patients with hormone sensitive prostate cancer.

NCT ID: NCT03518606 Not yet recruiting - Breast Cancer Clinical Trials

Metronomic Oral Vinorelbine Plus Anti-PD-L1/Anti-CTLA4 ImmunothErapy in Patients With Advanced Solid Tumours

MOVIE
Start date: June 20, 2018
Phase: Phase 1/Phase 2
Study type: Interventional

This is a phase I/II national, multicentre, multiple cohort, prospective open-label, non-randomised and non-comparative study, to evaluate the safety and activity of metronomic oral vinorelbine associated with durvalumab + tremelimumab combination immunotherapy for the treatment of advanced solid tumours.

NCT ID: NCT03513211 Not yet recruiting - Prostate Cancer Clinical Trials

Phase I/II Study of Hydroxychloroquine With Itraconazole With Biochemically Recurrent Prostate Cancer

HITMAN-PC
Start date: May 30, 2018
Phase: Phase 1/Phase 2
Study type: Interventional

Recent pre-clinical work has suggested that Itraconazole has an anti-cancer effect that works synergistically with hydroxychloroquine. This may delay the need for androgen deprivation therapy (ADT) and its associated toxicities in men with biochemically recurrent (BCR) prostate cancer. This study aims to determine feasibility, safety and efficacy of suba-itraconazole (SI) in combination with hydroxychloroquine (HQ) in the treatment of biochemically recurrent (BCR) prostate cancer as means of delaying time to commencement of androgen deprivation therapy.

NCT ID: NCT03507608 Not yet recruiting - Prostate Cancer Clinical Trials

Assessing Induction of Double Strand Breaks With Androgen Receptor Partial Agonist in Patients on Androgen Suppression

Start date: July 1, 2018
Phase: Early Phase 1
Study type: Interventional

This is a prospective, single-center, two-phase study to assess the efficacy of single pulsed-dose flutamide in creating double strand breaks (DSBs) in prostate cancer within patients receiving central androgen suppression and brachytherapy.

NCT ID: NCT03496142 Not yet recruiting - Prostate Cancer Clinical Trials

Perineal Versus Rectal Approach for Prostate Biopsy to Prevent Iatrogenic Infections

PRAPI
Start date: April 2018
Phase: N/A
Study type: Interventional

Retrospective reports from literature have shown a lower rate of infections for transperineal versus transrectal approach for prostate biopsies in the setting of prostate cancer suspicion. The aim of this study would be to compare in a prospective randomized trial the rate of infection with transperineal versus transrectal approach.