a 3.0T Magnetic Resonance Imaging Study

Primary Open Angle Glaucoma Clinical Trial

Official title:

The Central Nerve System Injury in Patients With Primary Open Angle Glaucoma

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT01346904
• Other study ID #: POAG3243
• Status: Not yet recruiting
• Phase: N/A
• First received: May 2, 2011
• Last updated: May 2, 2011
• Start date: May 2011
• Est. completion date: December 2012

Study information

• Verified date: May 2011
• Source: Huazhong University of Science and Technology
• Contact: n/a
• Is FDA regulated: No
• Health authority: China: Ministry of Health
• Study type: Observational

Clinical Trial Summary

Glaucomatous damage not only occurred to retinal ganglion cells in the eyes, but went across optic nerves, visual chiasm, lateral geniculate nucleus (LGN) and finally the visual cortex; the neural degenerations could be identified through the whole visual tract, which suggests the central nerve system may play a vital role in the progression of glaucoma. The investigators used MRI to investigate changes of visual pathway in vivo.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 200
• Est. completion date: December 2012
• Est. primary completion date: December 2012
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Primary open angle glaucoma diagnosed on the basis of glaucomatous optic disc cupping ratio (in particular, thinning of the inferior and/or superior rim, cup-to-disc ratio asymmetry of >0.2)

• matching glaucomatous visual field defects (European Glaucoma Society (2008) Perimetry )

Exclusion Criteria:

• optic neuropathy

• neurological disorder

• other diseases and use of systemic medications which affect optic nerve or the visual ?eld underwent complete eye examination and visual-field testing.

Study Design

Observational Model: Case Control, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

• Glaucoma
• Glaucoma, Open-Angle
• Primary Open Angle Glaucoma

Locations

Country	Name	City	State
n/a

Sponsors (2)

Lead Sponsor	Collaborator
Huazhong University of Science and Technology	Sun Yat-sen University