Primary Myelofibrosis Clinical Trial
Official title:
Myeloproliferative Neoplasms and Bone Structure
This is a clinical study to evaluate the effect of CMPN (Chronic myeloproliferative
neoplasm) to the bone.
The hypothesis is that patients with CMPN have a higher fracture-rate compared to the
background population. We expect to find a lower BMD using conventional DXA scan (dual
energy x-ray absorptiometry), and a change in other parameters using HR-pQCT
(high-resolution peripheral quantitative computerized tomography).Biochemical bone markers
is measured to support the hypothesis.
This is a clinical study to evaluate the effect of CMPN to the bone.
Three individual cohorts are defined; a cohort consisting of 50 patients with Polycythemia
Vera (PV), a cohort consisting of 50 patients with Essential Thrombocythemia (ET), and a
cohort consisting of 25 patients with Primary Myelofibrosis (PMF).
Patients are recruited from the Department of Hematology, Odense University Hospital.
Interventions consist of:
- Conventional DXA scan to measure Bone Mineral Density (BMD).
- Experimental HR-pQCT to assess geometry, strength and microstructure of the bone in 3
dimension.
- Blood-samples are collected and frozen for later analyses of Biochemical Bone Markers:
1-CTP, Ctx, ALP (alkaline phosphatase)and P1NP.
The outcome is compared to healthy control individuals.
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Observational Model: Case Control, Time Perspective: Prospective
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