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NCT03516565 Clinical Trial

Matrix Metalloproteinases's in Oral Biofluids During Pregnancy and Postpartum

Pregnancy Clinical Trial

Official title:
Modulation of Matrix Metalloproteinases-8, -9 and Endogenous Tissue Inhibitor-1 in Oral Biofluids During Pregnancy and Postpartum

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT03516565
Other study ID # BAP-18
Secondary ID
Status Completed
Phase
First received
Last updated
Start date April 1, 2013
Est. completion date September 1, 2015

Study information
Verified date April 2018
Source Adnan Menderes University
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The aim of this study was to investigate salivary and gingival crevicular fluid (GCF) levels of MMP-8, MMP-9 and TIMP-1 during 2/3 trimester of pregnancy and after delivery

Description:

MMP-8 and MMP-9 have been reported to reflect the inflammatory status in periodontal tissues and, therefore represent as potential biomarkers of periodontitis. The balance between tissue inhibitors of metalloproteinases (TIMPs) and MMPs play an important role in maintaining the integrity of healthy periodontium.

Recruitment information / eligibility
Status Completed
Enrollment 114
Est. completion date September 1, 2015
Est. primary completion date October 15, 2014
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Female
Age group 18 Years to 50 Years
Eligibility Inclusion Criteria:

- Pregnant group included women, who were in their second trimester (weeks 16-24) and third trimester (weeks 25-34)

Exclusion Criteria:

- (a) any known systemic disease, (b) periodontal treatment within the last six months, (c) patients having less than 10 teeth, (d) smokers and (e) individuals with BMI > 30 kg/m2

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• Saliva collection

• GCF collection

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
Adnan Menderes University

Outcome
Type Measure Description Time frame Safety issue
Primary Changing MMP-8 levels Salivary and GCF level measured by IFMA 6 months
Primary Changing MMP-9 levels Salivary and GCF level measured by ELISA 6 months
Primary Changing TIMP-1 levels Salivary and GCF level measured by ELISA 6 months
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