Aspirin for Prevention of Preeclampsia

Status Recruiting

Clinical Trial Summary

Prophylaxis with low-dose aspirin has been recommended to prevent preeclampsia, the rationale being that hypertension and abnormalities of coagulation in this disease are caused in part by an imbalance between vasodilating and vasoconstricting prostaglandins. Low-dose aspirin therapy inhibits thromboxane production more than prostacyclin production and therefore should protect against vasoconstriction and pathologic blood coagulation in the placenta. Initially, several single-center trials, mostly among women at increased risk for preeclampsia, demonstrated a substantial reduction in the risk of proteinuric hypertension as well as reductions in the incidences of preterm birth, infants small for gestational age, and perinatal death,

Clinical Trial Description

This will be a randomized control trial to estimate the efficacy of two doses (80 mg versus 160 mg) of aspirin for prevention of preeclampsia in High-Risk Pregnant Women identified in the first trimester to be at high risk. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03726177
Study type	Interventional
Source	Aswan University Hospital
Contact	hany f sallam, md
Phone	01022336052
Email	hany.farouk@aswu.edu.eg
Status	Recruiting
Phase	N/A
Start date	December 1, 2018
Completion date	January 1, 2021

View Details

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