Preeclampsia Clinical Trial
Official title:
Spinal Anesthesia in Severe Preeclampsia and Its Impact on Hemodynamics (Case Control Study)
The use of spinal anesthesia in pre-eclamptic pregnant woman is of considerable benefit, as these patients present particular hazards with general anaesthesia, such as concerns for rapid airway control and cerebral blood flow alterations during induction of general anaesthesia and intubation However, the incidence of hypotension is high during spinal anesthesia for Cesarean section and it may approach values up to 95 %.
The parturient will be allocated into one of two equal groups (n=30), a severe preeclampsia
group (A) and a normotensive group (B). All will receive colload (500 ml voluven) as a
coload via wide bore (16 Gauge ) cannula within 5-10 minutes during induction of spinal
anesthesia. Standard monitoring with electrocardiography, automated non-invasive arterial
pressure (NIAP) measurement, and pulse oximetry will be performed. Systolic arterial
pressure (SAP), mean arterial pressure (MAP) and diastolic arterial pressure (DAP) will be
monitored. Baseline values will be recorded in the supine position. Central venous line will
be inserted in severe preeclampsia group and central venous pressure will be measured every
10 minutes.
Spinal anesthesia will be induced with a total of 10 mg of 0.5% hyperbaric bupivacaine and
25 µg fentanyl (total volume 2.5 ml) at the L3-4 interspace in the sitting position then the
patient will be returned immediately to the supine position with left lateral tilt.
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Observational Model: Case Control, Time Perspective: Prospective
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