Vitamin D Deficiency Clinical Trial
Official title:
Nutrition and Body Composition in Acute Lymphoblastic Leukemia (Environment and Microenvironment in ALL #2)
Many adolescents with acute lymphoblastic leukemia (ALL) have been found to have low bone
density by the end of treatment. This can lead to long-term suffering in survivors due to
poor bone health. Vitamin D is known to be associated with bone health and previous research
has established that Vitamin D insufficiency is very common at diagnosis of ALL and worsens
over the course of treatment. Researchers have also learned that a relationship exists
between both Vitamin D and fat tissue and ALL and fat tissue.
In adolescents being treated for ALL as well as in early survivors, this randomized study
will therefore examine the effect of Vitamin D and calcium supplementation on correcting
Vitamin D insufficiency and on improving bone density in the context of changes in body
composition and body fat. Bone density will be measured by a radiology exam called qCT
(quantitative computed tomography) while body composition and body fat will be measured by a
different radiology exam called a DXA (dual energy x-ray absorptiometry scan) . The study
will also examine in depth the relationship between these three elements - Vitamin D
insufficiency, obesity, and ALL - and their impact on bone density.
n/a
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