Postoperative Pain Clinical Trial
Official title:
A Comparative Study of Efficacy and Safety of Lornoxicam Versus Etoricoxib After Total Knee Arthroplasty
The purpose of this study is to assess efficacy and safety of lornoxicam compared with that of etoricoxib after total knee replacement.
Total primary knee arthroplasty (TKA) remains a model of severe pain for major orthopedic
surgery. The concept of multimodal analgesia for the postoperative pain therapy is a routine
in many hospitals but the question is still under debate about the ideal combination between
techniques and drugs regarding early mobilization and low risk of complications.
After obtaining Ethical Committee approval and informed consent, 110 patients American
Society of Anesthesiologists score (ASA ) I-II undergoing knee replacement under spinal
anesthesia were randomized to receive postoperative either lornoxicam (8 mg per os (PO) /12
hours (h) for 48 h) or etoricoxib (120mg PO/24 h for 48 h) both administered in the
postoperative care unit, at the end of surgery.
The groups received postoperative analgesia when Numeric Rating Scale (NRS) over 3 with IV
Perfalgan in fixed dose 1g every 8 h and morphine (loading dose 0,1mg/kg and titration until
NRS under 3, followed by subcutaneous (SC) administration of ½ of the total loading dose on
demand for the following 48 h).The lornoxicam group received gastric protection with IV
pantoprazole.
The effectiveness was evaluated by the time from the initiation of spinal anesthesia until
the first analgesic dose at NRS over 3, the total amount of morphine in the first 24 and 48 h
postoperative, the side effects and necessary amount of adjuvant medication.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04633850 -
Implementation of Adjuvants in Intercostal Nerve Blockades for Thoracoscopic Surgery in Pulmonary Cancer Patients
|
||
| Recruiting |
NCT03181620 -
Sedation Administration Timing: Intermittent Dosing Reduces Time to Extubation
|
N/A | |
| Completed |
NCT04579354 -
Virtual Reality (VR) Tour to Reduce Preoperative Anxiety Before Anaesthesia
|
N/A | |
| Recruiting |
NCT06007378 -
Optimizing Postoperative Pain Control After Laparoscopic Colorectal Surgery
|
N/A | |
| Recruiting |
NCT05943015 -
Analgesic Efficacy of Quadratus Lumborum, Paravertebral Blocks
|
N/A | |
| Completed |
NCT04544228 -
Ketamine or Neostigmine for Serratus Anterior Plane Block in Modified Radical Mastectomy
|
N/A | |
| Completed |
NCT03678168 -
A Comparison Between Conventional Throat Packs and Pharyngeal Placement of Tampons in Rhinology Surgeries
|
N/A | |
| Completed |
NCT03286543 -
Electrical Stimulation for the Treatment of Pain Following Total Knee Arthroplasty Using the SPRINT Beta System
|
N/A | |
| Completed |
NCT03663478 -
Continuous TQL Block for Elective Cesarean Section
|
Phase 4 | |
| Completed |
NCT04176822 -
Designing Animated Movie for Preoperative Period
|
N/A | |
| Completed |
NCT05170477 -
Influence of Apical Patency Concept Upon Postoperative Pain After Root Canal Treatment
|
N/A | |
| Not yet recruiting |
NCT04561856 -
Fascia Iliaca Block Supplemented With Perineural Vs Intravenous Dexamethasone
|
Phase 4 | |
| Completed |
NCT03612947 -
TAP Block in Laparoscopic Cholecystectomy.
|
Phase 2 | |
| Recruiting |
NCT05974501 -
Pre vs Post Block in Total Knee Arthroplasty (TKA)
|
Phase 4 | |
| Completed |
NCT05995912 -
Efficacy and Safety of Etoricoxib-tramadol Tablet in Acute Postoperative Pain
|
Phase 2 | |
| Completed |
NCT04571515 -
Dose-Response Study of MR-107A-01 in The Treatment of Post-Surgical Dental Pain
|
Phase 2 | |
| Active, not recruiting |
NCT04190355 -
The Effect of Irrigant Types Used During Endodontic Treatment on Postoperative Pain
|
N/A | |
| Recruiting |
NCT05145153 -
Incidence of Chronic Pain After Thoracic Surgery
|
||
| Recruiting |
NCT03697278 -
Monitoring Postoperative Patient-controlled Analgesia (PCA)
|
N/A | |
| Completed |
NCT03650998 -
Transmuscular Quadratus Lumborum Block for Total Laparoscopic Hysterectomy.
|
Phase 4 |