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Post-Traumatic Stress Disorder clinical trials

View clinical trials related to Post-Traumatic Stress Disorder.

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NCT ID: NCT05260541 Terminated - Clinical trials for Post Traumatic Stress Disorder

A Clinical Trial of PRAX-114 in Participants With Post-Traumatic Stress Disorder

Start date: January 25, 2022
Phase: Phase 2
Study type: Interventional

This trial is comprised of a 4-week randomized, double-blind, placebo-controlled treatment period followed by an optional 8-week open-label extension (OLE) period. This trial will evaluate the efficacy and safety of oral PRAX-114 flexibly dosed at 40 to 60 mg for 4 weeks compared to placebo in adults with PTSD. The OLE period consisting of treatment with 40 mg PRAX-114 for 8 weeks will provide additional efficacy and safety data.

NCT ID: NCT04697693 Terminated - Clinical trials for Major Depressive Disorder

Antidepressant Response in Older Adults With Comorbid PTSD and MDD

Start date: March 3, 2021
Phase: Phase 4
Study type: Interventional

In the Investigator's ongoing studies of Posttraumatic Stress Disorder (PTSD) in older adults, it has been found that older adults with PTSD frequently meet the criteria for comorbid Major Depressive Disorder (MDD). Moreover, relative to trauma-exposed healthy controls (TEHCs), elders with PTSD manifest executive function deficits, fatigability, and mobility and physical function deficits that are consistent with what the investigator has observed in depressed older adults. Yet, the investigator has found that very few older adults with combined PTSD/MDD have received appropriate antidepressant treatment for their condition. These findings give rise to the questions of (1) how effective is antidepressant treatment for depressive symptoms in the context of PTSD/MDD and (2) are cognitive and physical function deficits in PTSD/MDD patients reversible with effective antidepressant treatment?

NCT ID: NCT04404712 Terminated - Clinical trials for Alcohol Use Disorder

FAAH Availability in Psychiatric Disorders: A PET Study

Start date: September 23, 2020
Phase: Early Phase 1
Study type: Interventional

The aim of the present study is to examine Fatty Acid Amide Hydrolase (FAAH) availability in humans, including healthy individuals and across a spectrum of psychiatric disorders in which alterations in the endocannabinoid system are observed.

NCT ID: NCT04394156 Terminated - Clinical trials for Post Traumatic Stress Disorder

Reducing Intrusive Memories in Refugees and Asylum Seekers With PTSD

Start date: July 7, 2020
Phase: N/A
Study type: Interventional

This research study is designed to investigate the use of a simple cognitive task for decreasing the number of intrusive memories of traumatic events experienced by refugees and asylum seekers with a diagnosis of Post-traumatic Stress Disorder (PTSD) currently living in the UK. The intervention includes a memory reminder cue, a 10-minute time gap and then around 20 minutes playing the mobile phone game Tetris, using mental rotation instructions. The study will have a multiple baseline case-series design (AB), with a randomised duration of baseline length up to three weeks. Thus, participants will complete a no-intervention phase of up to three weeks, followed by an intervention phase. Please see the intervention section for more details about the intervention sessions. Follow ups are conducted after each week to monitor the frequency of intrusive memories of trauma in a pen-and-paper diary. It is predicted that participants will report fewer intrusive memories after receiving the intervention than in the preceding baseline phase.

NCT ID: NCT04264520 Terminated - Clinical trials for Post Traumatic Stress Disorder

Initial Intervention Efficacy for an Online PTSD Intervention for Pregnant Women

Start date: June 5, 2020
Phase: N/A
Study type: Interventional

The current study aims to test a brief computer-assisted intervention (psychoeducation + skills) for pregnant women with elevated PTSD symptoms. In this open trial pilot feasibility study, 20 pregnant women in their first trimester will be invited to participate in the study if they endorse elevated PTSD symptoms. Oxytocin and cortisol will be measured at baseline, one month post-intervention, three months post-intervention, and post-delivery to inform the relationship between these hormones, PTSD symptoms, and peripartum/postpartum outcomes. In addition to receiving the psychoeducation + skills intervention during their first trimester, women will be offered a "booster session" intervention following delivery to enhance utilization of skills during a critical period for maternal mental and physical health outcomes.

NCT ID: NCT04185155 Terminated - Clinical trials for Post Traumatic Stress Disorder

Simple Cognitive Task After Trauma EKUT RCT

Start date: December 10, 2019
Phase: N/A
Study type: Interventional

This research study is designed to investigate the effects of a simple cognitive task (a memory cue following by playing the computer game "Tetris") on intrusive memories ("flashbacks") and other symptoms after a traumatic event. Patients presenting to a hospital emergency department soon after a traumatic event will be randomly allocated to either the simple cognitive task intervention or control. Participants will be followed up at one week and one month, and where possible 3 and 6 months. It is predicted that participants given the simple cognitive task intervention will develop fewer intrusive memories and less severe related clinical symptoms than those who are not. This will inform the future development of a simple technique to prevent distressing psychological symptoms after a traumatic event. Implementation and training aspects in a hospital context will also be explored. Patients use their smartphone for part of the intervention in the study.

NCT ID: NCT03966885 Terminated - Depression Clinical Trials

Zambia Common Elements Treatment Approach Pilot Study

ZCAP
Start date: June 24, 2019
Phase: N/A
Study type: Interventional

This is a randomized controlled trial (RCT) evaluating the effectiveness of an alcohol brief intervention alone compared to the brief intervention plus an evidence-based psychotherapy (CETA) in reducing alcohol misuse and co-occurring mental health problems among persons with HIV in Zambia.

NCT ID: NCT03898843 Terminated - Anxiety Clinical Trials

Assisted Animal Therapy: ReAnimal

ReAnimal
Start date: September 18, 2020
Phase: N/A
Study type: Interventional

Assisted animal therapy (AAT) is getting more and more used worldwide, in such areas as gerontology, psychiatry, or oncology. It is a complementary therapy, and benefits for patients are various, including decrease of anxiety. In ICU, some case reports exist, but no study has ever been made in order to prove its benefits, not even its feasibility. In ReAnimal, the investigator aims to compare a group of patients receiving assisted animal therapy, versus a group of patients not receiving it. Primary objective will be the evolution of anxiety scores between the 2 groups of patients. Secondary objectives will be the comparison of mood scores, post traumatic stress syndrome scores, pain scores, and physiologic parameters such as blood pressure, cardiac frequency. The investigating team will also compare multi drug resistant bacteria incidence between the 2 groups. In the assisted animal therapy group, patients will also be asked to answer a satisfaction questionnaire.

NCT ID: NCT03852628 Terminated - Clinical trials for Post Traumatic Stress Disorder

Kappa Opioid Receptor Antagonism for the Tx of AUD and Comorbid PTSD

Start date: May 20, 2019
Phase: Phase 2
Study type: Interventional

Objective: Evaluate the efficacy and physiological effects of sublingual buprenorphine (SL-BUP; Subutex) combined with extended-release injectable naltrexone (XR-NTX; Vivitrol) in the treatment alcohol use disorder of comorbid (AUD) and post-traumatic stress disorder (PTSD)

NCT ID: NCT03574974 Terminated - Clinical trials for Post-Traumatic Stress Disorder

Neurofeedback of Amygdala Activity for Post-traumatic Stress Disorder

PTSD
Start date: June 1, 2018
Phase: N/A
Study type: Interventional

The primary purpose of this study is to investigate the efficacy of neurofeedback (NF) of real-time functional magnetic resonance imaging (rt-fMRI) data of the amygdala with regards to the reduction of post-traumatic stress disorder (PTSD) symptoms. A secondary purpose of this study is to use fMRI as a method of investigating brain function in individuals with PTSD. This study approach provides a tool for probing the neurobiology of PTSD by (1) testing the critical role of the amygdala in this disorder, and by (2) examining how amygdala connectivity is related to both amygdala regulation and clinical symptoms.