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Post-stroke clinical trials

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NCT ID: NCT03751306 Not yet recruiting - Surgery Clinical Trials

Aerobic Exercise and Transcranial Low Laser Therapy in Patients With Central Nervous System Injury

Start date: January 14, 2019
Phase: N/A
Study type: Interventional

Objective of this protocol will be to evaluate the parameters related to the function of the musculoskeletal and cardiorespiratory system, through a rehabilitation and training program for people with acquired central nervous system and multiple sclerosis. The study will consist of volunteers with acquired CNS lesions and multiple sclerosis of both sexes, between 18 and 85 years old, and who wander with or without aid devices, randomly divided into 3 groups: Group 1 (cardiopulmonary treatment), Group 2 (cardiopulmonary treatment and transcranial photobiomodulation application) and Group 3 (cardiopulmonary treatment and placebo laser). All groups will receive aerobic training on a treadmill (Moviment®) with the aid of a suspension equipment (BrainMov® Physical Activity Station). The transcranial photobiomodulation (laser diode, λ = 810 nm, beam area 0.028 cm², power of 100 mW, power density of 3.5 mW / cm², energy of 3 Joules / point and energy density of 107.1 J / cm2) will be applied on the skin / scalp and the International System 10-20 at points F7, F8 and AFz will be used as reference for irradiation. Muscular activation, heart rate variability, lung volumes and capacities, fatigability, exercise tolerance, cognition and quality of life will be evaluated before, during, at the end and after two months of rehabilitation. The treatment proposed in this study, using transcranial photobiomodulation, is expected to improve muscle, sensory, cardiorespiratory, cognitive functions and to interfere positively in the quality of life of the volunteers.

NCT ID: NCT03645122 Not yet recruiting - Stroke Clinical Trials

Altered Connections in the Spinal Cord to Reduce Hand Impairment After Stroke

Start date: January 1, 2019
Phase: N/A
Study type: Interventional

The goals of this study are to leverage principles of spike timing-dependent plasticity (STDP) via non-invasive stimulation techniques to strengthen corticospinal transmission. Few studies have targeted the cortex after stroke in humans, and none have targeted the corticospinal-motoneuronal synapse in the spinal cord. This study, therefore, is a novel approach to studying neuroplasticity after stroke. Previous work in humans with incomplete spinal cord injury demonstrates that the resulting plasticity transiently enhances motor output, indicating that there is also therapeutic potential.

NCT ID: NCT03639116 Recruiting - Stroke Clinical Trials

Spinal Plasticity to Reduce Hand Impairment After Stroke

Start date: February 28, 2017
Phase: N/A
Study type: Interventional

The purpose of the study is to induce plasticity in corticospinal-motoneuronal synapses serving an intrinsic hand muscle of the hemiparetic limb in humans with stroke. Neurologically-intact controls are included to verify that an effect was present in absence of stroke. Outcome measures in controls also provide a reference point that help us to understand the size of the effect and mechanisms mediating the effect in the neurologically-intact system.

NCT ID: NCT03638570 Not yet recruiting - Stroke Clinical Trials

Altered Connections in the Spinal Cord to Reduce Hand Impairment After Stroke

Start date: October 2018
Phase: N/A
Study type: Interventional

The purpose of the study is to induce plasticity in corticospinal-motoneuronal synapses serving an intrinsic hand muscle of the hemiparetic limb in humans with stroke. Neurologically-intact controls are included to verify that an effect was present in absence of stroke. Outcome measures in controls also provide a reference point that help us to understand the size of the effect and mechanisms mediating the effect in the neurologically-intact system.

NCT ID: NCT02091739 Completed - Parkinson's Disease Clinical Trials

Clinical Study to Investigate the Efficacy and Safety of Two Dose Levels of NT 201 Versus Placebo in Treating Chronic Troublesome Sialorrhea in Various Neurological Conditions

SIAXI
Start date: April 2014
Phase: Phase 3
Study type: Interventional

The objective of this study is to investigate the efficacy and safety of two different dose levels of NT 201 (75 U or 100 U per cycle), compared with placebo, in reducing the salivary flow rate, and the severity and frequency of chronic troublesome sialorrhea that occurs as a result of various neurological conditions in adult subjects.