Post-polio Syndrome Clinical Trial
Official title:
Comparison of Activity and Fatigue of the Respiratory Muscles and Pulmonary Characteristics Between Post-Polio Patients and Healthy Controls: A Pilot Study
Background: Early diagnosis of respiratory impairment in Post-Polio (PPS) patients may delay
respiratory decline and future need of invasive respiratory aids.
Objectives: To compare pulmonary function measures, maximal respiratory pressure and
activity levels and fatigue of respiratory muscles between patients with PPS and healthy
controls.
Design: Cross-sectional study. Setting: Hadassah physical medicine and rehabilitation
department, Jerusalem. Patients: Patients with PPS (N=12; 6 males; age 62.1±11.6 years) able
to walk for 6 minutes without human assistance; age-matched healthy subjects (N=12; 4 males;
age 62.2±6.5 years).
Intervention: None. Measurements: A body plethysmograph was used to quantify forced
expiratory volume in the first second of a forced expiratory maneuver, vital capacity, slow
vital capacity, Residual Volume (RV), Total Lung Capacity (TLC), and Thoracic Gas Volume
(TGV). Also, RV to TLC ratio is calculated. A manometer was used to measure Maximal
Inspiratory Pressure (MIP) and Maximal Expiratory Pressure (MEP). A spirometer was used to
measure Maximal Voluntary Ventilation (MVV). Surface electromyography (sEMG) recorded
diaphragmatic muscle activity during rest and while performing MVV.
n/a
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