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Post-operative clinical trials

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NCT ID: NCT06101030 Recruiting - Post Operative Clinical Trials

Comparing Use of Incentive Spirometry With and Without Reminder

Start date: January 16, 2024
Phase:
Study type: Observational

This study is designed to determine if patients using an incentive spirometer with visual and auditory signals will increase their use of the incentive spirometer and prevent lung complications.

NCT ID: NCT06060366 Not yet recruiting - Clinical trials for Chronic Thromboembolic Pulmonary Hypertension

Impact of Pulmonary Endarterectomy on Sleep-Related Breathing Disorders in CTEPH: The IPES Trial

IPES
Start date: December 20, 2023
Phase:
Study type: Observational

Pulmonary hypertension (PH) has three main types, pre-capillary PH, post-capillary PH, and combined pre-capillary and post-capillary PH, and it is based on mean pulmonary arterial pressure (PAP) > 20 mmHg measured with a right heart catheterization (RHC). Chronic thromboembolic pulmonary hypertension (CTEPH) is mainly defined as a pre-capillary PH and classed as a Group IV PH. It was reported that 0.1-9.1% of individuals with pulmonary embolism develop CTEPH within two years after the initial diagnosis, and CTEPH is the only PH category that has a chance of being cured, mainly by pulmonary endarterectomy. Sleep-related breathing disorders (SRBD) are defined as obstructive sleep apnea (OSA) disorders, central sleep apnea (CSA) syndromes, sleep-related hypoventilation disorders, and sleep-related hypoxemia. An SRBD may also lead to an increase in PAP primarily during sleep and cause nocturnal hypoxemia. Although SRBDs were reported in patients with pre-capillary PH, most of the studies included patients with idiopathic PAH. Although the cause-and-effect relationship between pre-capillary PH and SRBDs is uncertain, it is known that mPAP may increase during sleep in patients with OSA . Less is known regarding the occurrence of SRBDs in CTEPH. Previously a few study showed relationship between SRBDs an CTEPH as the main type was OSA. Most of the studies evaluated preoperative occurance and incidance of SRBDs in CTEPH. Only one study performed post operative SRBD on a cardiorespiratory device was conducted the night before and one month after elective pulmonary endarterectomy. In our previous study we showed that severe nocturnal hypoxemia (NH) is highly prevelant in preoperative CTEPH patients and the most common two types of SRBD are OSA and isolated sleep related hypoxemia (ISRH) and age, mPAP and AHI are independent determinants of severe NH. (J. Clin. Med. 2023, 12, 4639 https://doi.org/10.3390/jcm12144639) In this present study we aimed to investigate occurrence of SRBDs and mortality 5 years after pulmonary endarterectomy operation.

NCT ID: NCT05825365 Withdrawn - Clinical trials for Neurofibromatosis Type 1

Selumetinib in Chinese Paediatric With Post-operative NF1-PNs, Phaseâ…¡, Double-Blinded, Placebo-Controlled Study

PROTECT
Start date: August 31, 2023
Phase: Phase 2
Study type: Interventional

This is a phase II, multicenter, randomised, parallel, double-blind, placebo-controlled study assessing the efficacy and safety of the MEKi selumetinib compared with placebo in Chinese paediatric participants with post-operative NF1-associated PNs.

NCT ID: NCT05123092 Completed - Analgesia Clinical Trials

Erectae Spinae Block Versus Intrathecal Morphine for Postoperative Analgesis in Lumbar Surgeries

Start date: January 20, 2021
Phase: N/A
Study type: Interventional

The study design will be double blinded retrospective controlled comparative study. The patients will be included in the study shoud be in the following category: - American Society of Anesthesiologists (ASA) physical status I, II - Age range from 18 and 70 years. The patients will be discarded from the study shoud be in the following: - patient refusal. - significant renal, hepatic and cardiovascular diseases. - Pregnancy. - Any contraindication to regional anesthesia such as local infection or bleeding disorders. - Chronic opioid use, history of chronic pain and cognitive disorders. - Lumbar spine lesion revision and dural tear. Postoperative pain will be evaluated using a visual analogue scale (VAS) score as primary outcome measure. demographic data ( Age, Weight, sex and height) , ASA classification ,mean operative times (min), time to the first rescue analgesic (min) ,intraoperative fentanyl consumption(microgram),postoperative opioid consumption ,sedation score, hemodynamics intraoperative and postoperative ( BP ,H R and oxgen saturation %) and complications as 2ry outcome measures.

NCT ID: NCT04213716 Completed - Pain Clinical Trials

Comparison of the Efficacy of Calcium Hydroxide With Silver Nanoparticle and Conventional Calcium Hydroxide Intra Canal Medications on Post-Operative Pain in Symptomatic Root Canal Treatment Failure Cases:

CSNIMSRRT
Start date: June 15, 2015
Phase: Phase 2
Study type: Interventional

The aim of this study is to measure and compare the effectiveness of nanosilver combined calcium hydroxide and conventional calcium hydroxide intracanal medications in reducing postoperative pain in patients with Symptomatic Root Canal treatment Failure .

NCT ID: NCT03157245 Recruiting - Critically Ill Clinical Trials

Incidence of Deep Vein Thrombosis on Central Venous Catheters in the Post Operative Period of Carcinologic Surgery

THROMBOCAT
Start date: June 2, 2017
Phase: N/A
Study type: Observational

The objective is to determine the incidence of thrombosis on central venous catheters in patients hospitalized in a surgical critical care unit, in the immediate postoperative period of urological or digestive carcinological surgery, and receiving parenteral nutrition.

NCT ID: NCT03030742 Completed - Opioid Use Clinical Trials

Postpartum Opioid Prescribing Patterns and Patient Utilization

Start date: June 1, 2017
Phase:
Study type: Observational

This study seeks to investigate the prescribing patterns and patient utilization of opioid pain medication in the postpartum setting. Postpartum women will be surveyed prior to hospital discharge and again at 2-4 weeks postpartum in order to assess the number of opioid tablets they used (in relation to the number prescribed), pain satisfaction, and storage/disposal of any remaining opioid tablets.

NCT ID: NCT02881385 Not yet recruiting - COPD Clinical Trials

Effects on Respiratory Patterns and Patient-ventilator Synchrony Using Pressure Support Ventilation

Start date: September 2016
Phase: N/A
Study type: Observational

Pressure Support Ventilation use Expiratory triggering sensitivity(Esense) to transfer inspiration to expiration,the value of Esense is fixed.That may lead to asynchrony between humans and ventilators,making people uncomfortable and prolonging weaning time.Some ventilators have auto cycle function Based on curves of pressure on respiratory patterns,it will make the transforming more synchrony with humans.Our prospective observational study will prove the superiority of the auto cycle function.