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Clinical Trial Summary

The purpose of this study is to evaluate the pharmacokinetics (PK), safety, and tolerability of aprepitant for the prevention of post-operative nausea and vomiting (PONV) in pediatric participants.

Post-operative aprepitant plasma concentrations will be evaluated with a non-compartmental analysis (NCA) at each dose and for each age cohort. Full PK profiles analyzed using population PK modeling and simulation will be described in a separate report.


Clinical Trial Description

Because the opportunity to collect specimens for PK analyses in children will be limited, a flexible sparse sampling scheme using ranges of collection times will be utilized which will limit the burden to participants. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT01732458
Study type Interventional
Source Merck Sharp & Dohme Corp.
Contact
Status Completed
Phase Phase 2
Start date February 12, 2013
Completion date September 26, 2016

See also
  Status Clinical Trial Phase
Completed NCT01725399 - Does First Oral Intake After Emergence Predict the Incidence of Post-operative Vomiting in Children? N/A
Completed NCT01592708 - Study of Anesthesia Techniques to Reduce Nausea and Vomiting After Jaw Corrective Surgery N/A