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Post-operative Pain for Total Knee Arthroplasty clinical trials

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NCT ID: NCT02466022 Completed - Clinical trials for Post-operative Pain for Total Knee Arthroplasty

Dexmedetomidine for Sedation in Total Knee Replacements

Start date: June 2015
Phase: Phase 3
Study type: Interventional

Dexmedetomidine has demonstrated benefits both in sedation, and post-operative pain control, with less respiratory depression than other common sedatives. Traditionally, dexmedetomidine has been used with a large loading dose and infusion, which has been known to cause dose-dependent negative side-effects (Abdallah et al., 2013). Single dose dexmedetomidine produces less negative side-effects, but still effective sedation and reduced post-operative pain (Jung et al., 2013). There is evidence for its benefits with general anesthesia but only a few studies exist investigating its benefits when administered for sedation purposes with spinal anesthesia, and no studies primarily examine post-operative opioid consumption. The investigators hypothesize that single dose dexmedetomidine for procedural sedation will reduce opioid consumption after total knee arthroplasty (TKA).