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Post-Operative Nausea and Vomiting clinical trials

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NCT ID: NCT03435003 Recruiting - Clinical trials for Post-operative Nausea and Vomiting

Designing Optimal Prevention and Management of Postoperative Nausea and Emesis for Patients Undergoing Laparoscopic Sleeve Gastrectomy

Start date: August 28, 2017
Phase: Phase 4
Study type: Interventional

Bariatric surgery remains the most effective therapy for obesity. Postoperative nausea and vomiting (PONV) are commonly reported following bariatric surgery. The proposed study focuses on the most common bariatric procedure performed, laparoscopic sleeve gastrectomy (LSG), and aims to assess the effect of a post-operative nausea and vomiting-specific intervention. The investigators hypothesize that the intervention group will experience a reduction of nausea-related prolonged hospital stay and significantly improve patient-reported quality of recovery from surgery and quality of life.

NCT ID: NCT03380754 Recruiting - Clinical trials for Post Operative Nausea and Vomiting

Effects of Preoperative Carbohydrate Rich Drinks on Immediate Postoperative Outcome in Total Knee Arthroplasty

PONV
Start date: July 15, 2017
Phase: N/A
Study type: Interventional

The aim of this study is to investigate the effect of preoperative carbohydrate rich drinks on postoperative nausea and vomiting in total knee arthroplasty. This is a prospective, double blinded, randomized controlled trial.

NCT ID: NCT03313479 Not yet recruiting - Clinical trials for Post Operative Nausea and Vomiting

the Effect of Three Different Analgesic Techniques on the Incidence of Postoperative Nausea and Vomiting

Start date: October 30, 2017
Phase: N/A
Study type: Observational

Postoperative nausea and vomiting (PONV) is a distressing adverse effect that may result in postoperative complications including bleeding, wound dehiscence, aspiration pneumonitis, as well as fluid and electrolyte imbalances Incidence of PONV after general anesthesia is about 30% in all post-surgical patients but up to 80% in high-risk patients despite advances in anesthetics and anesthesia techniques

NCT ID: NCT03297021 Recruiting - Clinical trials for Post-operative Nausea and Vomiting

Effects of Ondansetron Dose and Timing on Post-operative Nausea and Vomiting

Start date: October 23, 2017
Phase: Phase 4
Study type: Interventional

The aim is to evaluate the effectiveness of three different regimens of prophylactic ondansetron on the incidence and severity of post-operative nausea and vomiting.

NCT ID: NCT03165123 Not yet recruiting - Clinical trials for Post-operative Nausea and Vomiting

Effect of Using Erythromycin A Versus Placebo With Dexamethasone in Prevention of Post-spinal Nausea and Vomiting.

Start date: June 1, 2017
Phase: Phase 4
Study type: Interventional

Postoperative nausea and vomiting is defined as any nausea, retching, or vomiting occurring during the first 24-48 h after surgery in inpatients. Postoperative nausea and vomiting is one of the most common causes of patient dissatisfaction after anesthesia, with reported incidences of 30% in all post-surgical patients and up to 80% in high-risk patients. In addition, postoperative nausea and vomiting is regularly rated in preoperative surveys, as the anesthesia outcome the patient would most like to avoid. While suture dehiscence, aspiration of gastric contents, esophageal rupture, and other serious complications associated with postoperative nausea and vomiting are rare, nausea and vomiting is still an unpleasant and all-too-common postoperative morbidity that can delay patient discharge from the post-anesthesia care unit and increase unanticipated hospital admissions in outpatients.

NCT ID: NCT02881840 Completed - Clinical trials for Post-operative Nausea and Vomiting

Mass-balance Study of [14C]-APD421 in Healthy Volunteers

Start date: August 2016
Phase: Phase 1
Study type: Interventional

Open-label, non-randomised, single dose study in 6 healthy male subjects to assess the mass balance recovery, metabolite profile, metabolite identification and pharmacokinetics of 14C-labelled APD421

NCT ID: NCT02473042 Recruiting - Breast Cancer Clinical Trials

Intraoperative Acupoint Stimulation to Prevent Post-Operative Nausea and Vomiting (PONV)

Start date: February 2016
Phase: N/A
Study type: Interventional

The goal of this clinical research study is to learn if light electrical stimulation to the wrist area during surgery is feasible in women having breast surgery.

NCT ID: NCT02223377 Active, not recruiting - Pain Clinical Trials

Satisfactory Analgesia Minimal Emesis in Day Surgeries

SAME-Day
Start date: January 2015
Phase: N/A
Study type: Interventional

Currently nearly 70% or more surgeries are being done as ambulatory (day care) procedures as they offer significant benefit to the patients as well as to the hospitals. Inadequate pain relief (30%-40%) and nausea-vomiting form the leading factors affecting the quality of care and hence its efficiency. Opioids form the primary modality to treat moderate to severe pain, but can also cause significant nausea-vomiting and other side effects. Although hydromorphone is five times more potent than morphine, in equianalgesic doses they both could provide similar pain relief. They both exert no ceiling effect for their analgesia, and hence incomplete or inadequate analgesia is related to the appearance of side effects. In this study the investigators shall assess the proportion of patients who satisfy the outcome of 'satisfactory analgesia with minimal nausea-vomiting' in ambulatory surgeries, assessed at 2 hours after surgery. Patients would be randomized to receive either morphine or hydromorphone in the surgical recovery area. All personnel involved with the study would be blinded. The investigators will also look to assess the time to discharge and other side effects. This will help to choose the better drug, thereby improving pain relief and side effects, and also the efficiency of health care delivery.

NCT ID: NCT02102555 Recruiting - Post Operative Pain Clinical Trials

A Single Dose of Intravenous (IV) Acetaminophen Verses Placebo in the Pre-operative Setting and Outcomes on Post-operative Pain, Nausea and Vomiting

IV
Start date: October 2013
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine whether a single dose of IV acetaminophen can improve post-operative pain, nausea, and vomiting in the outpatient setting. Patient satisfaction, time to readiness of discharge, and the amount of opiates post operatively will also be measured.

NCT ID: NCT01657786 Completed - Clinical trials for Post Operative Nausea and Vomiting

Association of 5-HT3 Receptor Gene Polymorphism With the Efficiency of Ondansetron for Postoperative Nausea and Vomiting

Start date: May 2008
Phase: N/A
Study type: Interventional

Postoperative nausea and vomiting (PONV) is a common and distressing complication in patients undergoing general anesthesia. However, although 5-hydroxytryptamine type 3 (5-HT3) receptor antagonists have significantly reduced PONV, it is reported that over 35% of patients treated with ondansetron experience PONV. Though the cause of failure in ondansetron treatment is not clear, the investigators assumed that polymorphism in the 5-HT3 receptor gene would contribute to such inter-individual variation. In this study, the investigators examine whether the polymorphisms of 5-HT3 receptor gene affect the efficacy of ondansetron to prevent PONV in patients undergoing general anesthesia for laparoscopic surgery.